Journal/Magazine Articles
Permanent URI for this collectionhttp://repository.kln.ac.lk/handle/123456789/13
This collection contains original research articles, review articles and case reports published in local and international peer reviewed journals by the staff members of the Faculty of Medicine
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Item Neurological disorders associated with COVID-19 in Sri Lanka(BioMed Central,, 2023) Chang, T.; Wijeyekoon, R.; Keshavaraj, A.; Ranawaka, U.; Senanayake, S.; Ratnayake, P.; Senanayake, B.; Caldera, M.C.; Pathirana, G.; Sirisena, D.; Wanigasinghe, J.; Gunatilake, S.; ASN COVID-19 Study GroupBACKGROUND: Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. METHODS: COVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 – May 2022. Data was collected using a structured data form that was electronically transmitted to a central repository. All patients were evaluated and managed by a neurologist. Data were analysed using simple descriptive analysis to characterise demographic and disease related variables, and simple comparisons and logistic regression were performed to analyse outcomes and their associations. RESULTS: One hundred and eighty-four patients with neurological manifestations associated with COVID-19 were recruited from all nine provinces in Sri Lanka. Ischaemic stroke (31%) was the commonest neurological manifestation followed by encephalopathy (13.6%), Guillain–Barre syndrome (GBS) (9.2%) and encephalitis (7.6%). Ischaemic stroke, encephalitis and encephalopathy presented within 6 days of onset of COVID-19 symptoms, whereas GBS and myelitis presented up to 10 days post onset while epilepsy and Bell palsy presented up to 20 – 40 days post onset. Haemorrhagic stroke presented either just prior to or at onset, or 10 – 25 days post onset of COVID-19 symptomatic infection. An increased frequency of children presenting with encephalitis and encephalopathy was observed during the Omicron variant predominant period. A poor outcome (no recovery or death) was associated with supplemental oxygen requirement during admission (Odds Ratio: 12.94; p=0.046). CONCLUSIONS: The spectrum and frequencies of COVID-19 associated neurological disorders in Sri Lanka were similar to that reported from other countries, with strokes and encephalopathy being the commonest. Requiring supplemental oxygen during hospitalisation was associated with a poor outcome.Item The Physician neurologist:what do they do?what should they do?and why don't they?(Ceylon College of Physicians, 2002) Gunatilake, S.No Abstract AvailableItem The Course of epilepsy(1996) Gunatilake, S.Item Atlanto-axial subluxation:importance of early recognition(The Kandy Society of Medicine, 1996) Gunatilake, S.; Seneviratne, S.L.; Premawardhena, A.P.; de Silva, H.J.We report three cases which illustrate the importance of the early recognition of atlanto-axial subluxation by being aware of the disorders it is often associated with.Item Stroke: Infarct or haemorrhage - Does it matter?(The Kandy Society of Medicine, 1995) Gunatilake, S.Item Laughing seizures due to a midline intraventricular neoplasm in tuberous sclerosis(British Medical Association, 1995) Gunatilake, S.; de Silva, D.G.H.Laughing seizures have been described in association with hypothalamic hamartomas and precocious puberty. Laughing seizures due to a neoplasm arising from the floor of the left lateral ventricle extending down towards the hypothalamus in a child with tuberous sclerosis is reported. This combination has not been reported before and emphasises the importance of imaging to diagnose such midline lesions in children with paroxysmal laughing.Item Strokes - family physician's perspective(College of General Practitioners of Sri Lanka, 1993) Gunatilake, S.