Chikitsa
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Item Medicinal importance of Ferula asafetida oligo-gum resins against infective diseases(Journal of Medicinal Plants Studies 2020, 2020) Dissanayake, K.G.C.; Perera, W.P.R.T.Ferula foetida oligo-gum resin containing phytochemicals with anti-viral properties. In order to investigate medicinal values of ferula assa-foetida a literature searches were performed through PubMed and PMC academic publications. It contains five sesquiterpene cumarines namely, conferone, badrakemin, feslol, Isosamarcandin and samarcandin with anti-viral properties against Rhinovims (HR V) and Influenza A HINI_ Farnesiferol C and Famesiferol b are novel chemical scaffolds with HR V -2 inhibiting potential at low micromole and mode of inhibition action was prevention of rhinovims adsorption (HR V-2) and/or uncoatmg of the capsid of virus. 5'S-hydroxyumbe11iprenin and 8'-acetoxy- 5'S-hydroxyumbe11iprenin, methyl galbanate, galbanic acid, famesiferol-C, famesiferol-A, conferol showed greater potency against influenza A vims (H IN 1) (IC50 0.26-0.86 pg/mL) than amantadine. Several studies demonstrated that cytotoxic and antitumor activity of Galbanic acid. Additionally, exhibits anti-bacterial effects, anti—diabetic effects, anti- fungal, antiulcer genic effect and hypotensive effects. Asafoetida oligo-gum resin will be beneficial in anti-viral drug productions against disease forming viruses.Item Potential of Inhibiting the Receptor Binding Mechanism of SARSCOV-2 Using Phytochemical Extracts of Medicinal Herb; Moleculer Docking Study(Global Journal of Engineering Science and Research Management, 2020) Rajapaksa, R.M.H.; Perera, B.T.; Nisansala, M.J.; Perera, W.P.R.T.; Dissanayake, K.G.C.The Corona Viral Infective Disease (COVID-19), which leads to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is caused a pandemic situation globally. World Health Organization (WHO) declared that COVID-19 as a Public Health Emergency of International Concern (PHEIC) on January 30, 2020. Intend of this study is divulge the chemistry behind the phenomenon of viral (SARS-CoV-2) attachment on human epithelial cells as well as evaluate the receptor blocking abilities of selected herbal compounds. Significant anti- viral compounds were identified via review process of medicinal plants and Ferula asafetida, Glycyrrhiza glabra, Curcuma longa, Zingiber officinale etc. are widely used plant species for drugs against viral infectious diseases in Ayurveda medicine. Molecular docking prognosis have been carried out to demonstrate any possible secondary metabolites present in several anti-microbial herbs that could act as blocking agents ofACE2 and GRP78 receptors of epithelial cells to baffle the binding of receptor-binding domain (RBD) sections of SARS-CoV-2. Computational findings reveal that Phyto-chemicals such as Conferone, Samarcadin, Bdrakemin Famesiferol A, Femesiferol C and Galbanic acid isolated from Ferula asafetida have intensive binding energies for ACE2 receptor binding process. Apart from that Hederagenin and Ursolic also shows highest inhibitory potential towards human ACE2.When considering GRP78, almost all isolated compounds in oligo-gum resins ofFeru1a asafetida trot out perfect binding ability towards the active site of GRP78 receptor. Hence, it is worth to pay more attention on natural phytochemicals for mitigating of human infections.Item Root/Stem Extracts of Glycyrrhiza glabra; As a Medicinal Plant Against Disease Forming Microorganisms(International Journal of Sciences: Basic and Applied Research (IJSBAR),, 2020) Dissanayake, K.G.C.; Weerakoon, W.M.T.D.N.; Perera, W.P.R.T.Nature is one of the major sources of medicines since the beginning of human civilization. Different counties around the globe have been used different plant materials to overcome varieties of ailments from simple cough to hepatitis to more complexes like SARS and most recently Covid 19. This review is an effort to emphasis the phytochemical and chemical constituents of G. glabra and their mechanisms against disease forming microorgamsms. This traditional plant which is well known in Sri Lanka as "Welmi" is belongs to family Leguminosae/ Fabaceae. Chemical constituents of G. glabra like isoliquiritine, isoflavones, glycyrrhetic acid, saponin and their derivatives have been examined for their pharmacological activities. Most critical chemical compounds which isolated from the root/stem extract of the G glabra are Glycyrrhizin and Glycyrrhetic acid. Glycyrrhizin is a prominent triterpenoid contain in Glycyrrhiza glabra which is responsible for the sweet taste of its roots. Glycyrrhizin act as anti-viral compound in tun) ways. It is able to inhibit the replication process of some RNA viruses such as SARS like corona type virus. Another process is acting as an immunostimulator. It has been used to treat patients suffering from chronic hepatitis C virus and HIV-I patients owing to its capability of stimulating endogenous viral defense mechanisms.Item Immunomodulatory Efficiency of Tinospora Cordifolia Against Viral Infections(World Journal of Pharmaceutical and Medical Research, 2020) Dissanayake, K.G.C.; Perera, W.P.R.T.; Premasinghe, N.Most of the cases, viral infected patients are suffering from secondary infections. Apart from that, due to the exhausted Immune system patients more vulnerable to secondary Infections and various diseases. Dysfunction of the immune system is responsible for multiple illnesses, such as arthritis, ulcerative colitis, asthma, allergies, parasites, cancer, and infectious diseases. So, medicinal plants and their active components are becoming increasingly relevant as a source of immunomodulatory agents. T. cordifolia stem extracts or the isolated compounds of the plant exhibits amazmg immune stimulatory effects in various ways isolated compounds of T. cordifolia such as N-methyl-2-pyrrolidone and Il-hydroxymustakone, Magnoflorme and Tinocordiside shows immunomodulatory effects by enhancing Reactive Oxygen Species (ROS) generation which causes to augment the Immune response. T. cordifoüa extract exhibits a considerable effect of the immunostimulation in HW positive patients and, increases the phagocytosis and intercellular killing capacity by increasing the survival rate and polymorphonuclear leucocyte function. In addition to that, a novel (1,4)-∝-D-glucan from T. Cordifoüa activates the immune system by activatmg macrophages via of TLR6 signaling and NF-kB activation mechanism, leading to cytokine and chemokme production. Immunoductatory protem (Imp) obtained from the dry stem powder of Tinospora cordifoüa is significant for augmenting the various immunological activities in the human body. Hence, more attention should be focused on the phytochemistry and their applications of the Tinospora cordifolta for Immune enhancements as well as reduce secondary infections risks along with the viral infections.Item Potential of the Pathogenic Microorganisms Mitigation Using Rhizome Extract of Acorus Calamus as a Medicinal Herb(World Journal of Pharmacy and Pharmaceutical Sciences, 2020) Dissanayake, K.G.C.; Perera, B.T.; Perera, W.P.R.T.Acorus calamus exhibits polyploidy and phytochemical coruyosition also depends upon the ploidy. Scented leaves and rhizomes have been traditionally used m Ayurveda medicine for bronchitis, cough, fever, asthma and digestive problems. Pharmacological studies have revealed that Acopus calamus and its major constituents, particularly P-asarone and a-asarone possesses a wide range of amazing pharmacological activities such as anticonvulsant, acetylcholinesterase inhibitory, memory enhancing anti-inflammatory, antioxidant, sedative, CNS depressant, behavioral changes anticancer, cardiovascular, cytoprotective, antidiarrheal, and immunosuppressive activities. In addition to the above-mentioned pharmacological actions, antibacterial, antifungal, antiviral, anthelmintic and insecticidal activities are also reported.