Chemistry
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Item Hypoglycemic and Anti‑lipidemic Properties of Cinnamomum zeylanicum (“Sri Wijaya” Accession) Water‑soluble Nutraceutical in Streptozotocin‑induced Diabetic and Healthy Wistar Rats(Pharmacognosy Magazine, 2021) Jayawardena, B.; Madushika Wariyapperuma, W.N.; Thammitiyagodage, M.; Karunakaran, R.; Sisira Kumara, W.S.Background: Hyperglycemia is a serious health crisis worldwide, and more than 90% of the Sri Lankan patients effected with the condition have diabetes mellitus type 2. Natural therapeutic agents can manage the progression of the disease. Objectives: To investigate the hypoglycemic and antilipidemic effects of Cinnamomum zeylanicum (“Sri Wijaya” accession) water‑soluble nutraceuticals in diabetic‑induced and healthy Wistar rats. Materials and Methods: The diabetic and nondiabetic Wistar rats were treated with Cinnamon pressured water, Cinnamon decoction, pretreated pressured water Cinnamon extract for 1 month. The results were compared with the group treated with the positive control, Acarbose untreated normal group. Blood glucose and other biochemical parameters were estimated using commercial test kits. Results: There was a significant difference in the fasting serum glucose, food consumption, and water consumption in rats with induced diabetes. The total cholesterol level was significantly decreased in the normal groups treated with Cinnamon extracts, compared with the untreated groups. There was a significant increase in high‑density lipoprotein cholesterol levels in the normal group treated with pressured water Cinnamon extract and decoction when compared with the Acarbose‑treated diabetic group. Alanine aminotransferase (ALT) levels were significantly higher in the diabetic group treated with Acarbose than in all Cinnamon‑treated groups. However, no significant difference was shown in normal rat groups for aspartate aminotransferase and ALT. Conclusion: Cinnamon nutraceuticals have the potential to reduce hyperglycemia in diabetic rats. Cinnamon extracts may inhibit α‑amylase and α‑glucosidase enzymes in rat pancreatic tissues.Item Yoga-based Lifestyle Intervention for Prevention and Management of Type 2 Diabetes Mellitus and Associated Complications: A Clinical Research Review(Indian Journal of Medical Biochemistry, 2020) Dewangani, H. N.; Jayawardena, B.; Wijayagunarathne, H. S. P.Type 2 diabetes mellitus (T2DM) has become a major health challenge in the 21st century. Prevention and management of this metabolic disease could be achieved by healthy lifestyle interventions. Yoga is one such lifestyle intervention practice that has been identified and proved its beneficial effects on T2DM through several studies. The purpose of this comprehensive review was to assess the available evidence from both short-term and long-term studies regarding the beneficial effects of yoga intervention on adult patients with T2DM and the significant impact on diabetes-related risk indices. According to the evidence of past literature used for this review, yoga plays a significant role in the prevention and management of T2DM through the improvement of weight, blood pressure, glycemic parameters, lipid profile, and oxidative stress. Side effects or complications due to yogic practices have not been mentioned up to date in any study conducted. To conclude, most of the findings suggest that yoga may play a vital role in the prevention and management of T2DM, but the lack of standard research studies performed in a diverse population is a big barrier to make evidence-based conclusions. Additional high-quality, long-term investigations should be performed in diverse populations to evaluate the effectiveness of yoga in the prevention and management of T2DM and its complications.Item Fungicidal activity of essential oils of Cinnamomum zeylanicum (L.) and Syzygium aromaticum (L.) Merr et LM Perry against crown rot and anthracnose pathogens isolated from banana(Blackwell Science Ltd., 2002) Ranasinghe, L.; Jayawardena, B.; Abeywickrama, K.Aims: To develop a post-harvest treatment system against post-harvest fungal pathogens of banana using natural products. Methods and Results:Colletotrichum musae was isolated and identified as the causative agent responsible for anthracnose peel blemishes while three fungi, namely Lasiodiplodia theobromae, C. musae and Fusarium proliferatum, were identified as causative agents responsible for crown rot. During the liquid bioassay, cinnamon [Cinnamomum zeylanicum (L.)] leaf, bark and clove [Syzygium aromaticum (L.)] oils were tested against the anthracnose and crown rot pathogens. The test oils were fungistatic and fungicidal against the test pathogens within a range of 0·03−0·11% (v/v). Conclusions: Cinnamon and clove essential oils could be used as antifungal agents to manage post harvest fungal diseases of banana. Significance and Impact of the Study: Cinnamon and clove essential oil could be used as alternative post-harvest treatments on banana. Banana treated with essential oil is chemically safe and acceptable to consumers. Benomyl (Benlate), which is currently used to manage fungal pathogens, can cause adverse health effects and could be replaced with volatile essential oils.Item Phenolic extracts of coconut oil cake: a potential alternative for synthetic antioxidants(2016) Seneviratne, K.N.; Prasadani, W.C.; Jayawardena, B.Limitations of natural antioxidants include relatively low antioxidant activity, narrow range of food systems where the antioxidants are effective and limited thermal stability compared to synthetic antioxidants. In the present study, the phenolic extract of coconut oil cake (COCE) was tested for antioxidant activity-related food stabilization. Heat stabilities of COCE and synthetic antioxidants were determined by measuring the induction time of sunflower oil enriched with heat-treated antioxidants. In the β-carotene-linoleate emulsion used for testing antioxidant activity, COCE can retain 96 ± 2% of initial colour intensity while BHT can retain 89 ± 2% of initial colour intensity at 60 μg mL–1 concentration after two hours. TBARS contents (MDA equivalents / kg of meat) in COCE-treated and control pork samples after 14 days was 2.80 ± 0.57 and 22.55 ± 2.30 respectively. Heat stability varies in the order butylated hydroxytoluene (BHT) < (butylated hydroxyanisole (BHA) < COCE < tertiary butylhydroxyquinone (TBHQ). The results of these experiments suggest that COCE is a versatile and thermally stable natural antioxidant mixture effective in stabilizing many food systems.Item Shelf Life of Leafy vegetables Treated with natural Essential oils’(Sri Lanka Association for the Advancement of Science, 2008) Niharepola, D.A.; Jayawardena, B.Fresh product of vegetables typically contains a complex mix of microorganisms. To prolong the shelf life of vegetables, the growth of microbial population must be controlled and washing and removal of damaged tissues are employed to reduce initial high counts. Clean sanitations are essential because storage life is shorter with high initial microbial loads. Chemical sanitations have a negative impact. Naturally occurring antimicrobial product healthier for environment and humans. Essential oils have antimicrobial properties. We investigated the in vitro antimicrobial activity of Cinnamon leaf oils (Cinnamon zeylanicum) on the native micro flora of “Gotukola” (Centiella asiatica). Fresh Gotukola samples were selected with uniformity of color, size and physiological damage were discarded. Leaves were washed 3 times with tap water and allowed to remove surface moisture. Leaves were hand sprayed on both sides with essential oils at minimum inhibitory concentration (MIC) 0.06 ml/100ml v/v that is the concentration that produced a 90% in vitro inhibition of the native micro flora of Gotukala. In Control samples leaves were sprayed with tap water. After spraying 50g of the leaves were placed in low- density polyethylene (LDPE, 150 gauge) bags 0f 20 X 30cm2 surface area. The bags were sealed and stored at 50C with 97 % RH. At 3, 5 &7 days of storage samples were taken for determination of microbiological test include the total plate count (TPC), coliforms, E-coli and Salmonella, nutritional value (fiber, moisture, ash & ascorbic acid) & sensory properties. For determination of microbiological tests International Standard were used. Moisture, Ash, Fiber & Ascorbic acid content of the leaves were determined according to the standard methods. Leaves were evaluated for their sensory properties color, appearance, taste, and aroma, overall acceptability by providing samples and a questionnaire to six trained panelists. There was no effect due to essential oil treatment on nutritional value of Gotukola samples when compare the treated samples and control samples. Ascorbic acid content of the sample decrease with the storage time. TPC was low in samples treated with essential oils than control samples. Initial TPC of samples before essential oil treatment was 3.67× 102 cfu/g. Seven days after storages at 50C in control sample & treated sample TPC were 2.45×102 & 1.48 × 102 cfu/g respectively. Coliform count was also low in samples treated with essential oils (40 × 101 cfu/g) than control samples (110 × 101 cfu/g). The Salmonella count and E. coli count of all samples were nil. On the sensory attributes of the samples the panelists did not find difference among controls & treated samples. Throughout the storage time, no evidence of softening or rot was found on any of the samples. Therefore, we can conclude that cinnamon leaf oil can be used as naturally occurring sanitizing compound in leafy vegetables.