Conference Papers
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This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine
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Item Prevalence of covishield COVID-19 vaccine (ChAdOx1 nCoV-19) adverse effects among health care workers in Sri Lanka(Elsevier, 2022) Manilgama, S.R.; Hettiarachchi, N.M.; Jayasinghe, K.I.; de Silva, S.; Wanigaratne, T.; Jayalath, T.; Bandusiri, R.P.; Suganthan, N.; Sudarshan, P.; Pathirage, M.; Rajaratnam, N.; Senaratne, G.; Rajapaksha, V.; Wickramasinghe, A.; Kulaweera, M.T.D.PURPOSEA Community vaccination programme is the best approach to combat COVID-19 pandemic. The first priority was given to the health care workers (HCWs) with the introduction of Indian Covishield (ChAdOx1 nCoV-19) vaccine to Sri Lanka since February 2021. An independent post-vaccine surveillance is important to identify the occurrence of adverse effects(A/E) in the population. METHODS & MATERIALSA multicentered cross-sectional survey was conducted in four provinces of Sri Lanka to estimate the prevalence of A/E after covishield vaccination A/E among HCWs after the first dose. A self-administered questionnaire was used to gather demographic data and A/E. Data was analysed using descriptive statistics. RESULTS Of 4834 participants, 3500(72.4%) were females. The median age was 42.23(SD±9.64) years. Only 0.8%(n=31) persons has had Covid infection in the past. 2.2% were breastfeeding mothers and 0.2% were pregnant ladies.87.4% of persons had at least one A/E and 53.1% had local A/E. Body aches(68.2%), headaches(63.8%), fever(58%), chills 51.4%), fatigue(41.2%), arthralgia(38.1%) and rigors (32%) were the most commonly reported systemic A/E. Most of the systemic A/E were more prevalent among the ≤42-year-old group, and females. Their duration was mainly 24 hours. Mean duration of onset of fever is 9.76 hours. Pain and redness at the site were the most commonly reported local A/E. All of the local A/E were more prevalent among the ≤42-year-old group and females. Mean duration of pain at the site is 4.47 hours. 1.7%(n=61) had reactions within first 20 minutes. 0.08%(n=4) developed anaphylaxis, 0.8%(n=31) had urticaria. 15.4% had at least one comorbidities but there were no significant association between having a comorbidity and developing systemic or local. 1.3% had history of drug or food allergies, they did not show significant relation to current vaccine induced allergies or anaphylaxis. 69.2% attended the routine work despite having minor A/E. 0.13%(n=7) were hospitalised and treated. 22.4% were stayed at home and rested for 24-48 hours due to A/E. CONCLUSION Eventhough more than 60% reported minor A/E, there were only a few serious A/E. A/E were more prevalent in younger age and females. Overall, the first dose of the Covishield vaccine was well-tolerated by HCWs.Item Adverse events following first dose of ChAdOxI nCoV-19 (Covishield) among health care workers in Sri Lanka(Sri Lanka College of Internal Medicine, 2021) Manilgama, S.R.; Hettiarachchi, N.M.; Jayasinghe, I.K.; de Silva, S.; Jayalath, T.; Wanigaratne, T.; Bandusiri, R.P.; Suganthan, N.; Sudarshan, P.; Pathirage, M.; Rajaratnam, N.; Senaratne, G.; Rajapaksha, V.; Wickramasinghe, A.; Kulaweera, M.T.D.Introduction: A community vaccination programme is crucial to combat COVID-19 pandemic. An independent post-vaccine surveillance is important to identify adverse events following immunization (AEFI) in the population. Objective: To estimate the prevalence of AEFI after covishield vaccination among all categories of health care workers (HCWs) after the first dose. Methods: A multicentred cross-sectional survey was conducted in six provinces. A self-administered questionnaire was used to gather demographic data and AEFI. Results: Of 5140, 67.8% were females. The mean (SD) age was 40.69 (±10.07) years. At least one comorbidity was reported in 15.4%, At least one AEFI was reported in 86.6% and 49.3% had local AEFI. Bodyaches(54.4%), headaches (57.3%), fever (58.4%), chills(51.2%)( fatigue(37.5%) and arthralgia (36%) were the most reported systemic AEFI. Majority lasted <24 hours. Pain and redness at the site were the most reported local AEFI. Mean duration of onset of fever and site of pain was 6.65 and 9.67 hours respectively. The population was divided into two groups according to the mean age; <40 and >40 years and, study parameters were compared. Most of the systemic (fever, nausea, fatigue, itching) and all local AEFI were significantly higher among the <40-year-old group. Reactions occurred within first 20 minutes in 2%. Anaphylaxes developed in 12 patients. History of an叩hylaxis, drug, or food allergies were reported in 0.6%, 2.8%, 6.7% respectively, they didn't show significant relation to current vaccine induced allergies or anaphylaxis. Despite having minor AEFI, 71.1% attended routine work while 0.2% were hospitalised and treated.Item Metabolic syndrome and risk of endometrial carcinoma among asymptomatic, postmenopausal, urban Sri Lankan females: a community cohort follow-up study(Wiley Publishing, 2017) Dias, T.; Niriella, M.; de Silva, S.; Motha, C.; Palihawadana, T.S.; Ediriweera, D.; de Silva, J.OBJECTIVES: Metabolic syndrome (MetS) has been recognised as a risk factor for malignancies. The aim of this study was to evaluate the association of MetS and risk of endometrial carcinoma (EC), by measuring endometrial thickness (ET). METHODS: The Ragama Health Study (RHS) recruited 35-64-year-old female cohort by age-stratified random sampling in 2007 and re-evaluated them in 2014, using a structured interview, anthropometric measurements and biochemical tests. Liver ultrasound to detect fatty liver was performed in 2007. Pelvic ultrasound to detect ET was performed in 2014 among consenting participants. MetS was diagnosed on established International Diabetes Federation (IDF 2012) criteria. Increased ET was defined as >5mm. Simple logistic regression was used to screen variables and multiple logistic regression was used to obtain adjusted effects of risk factors for increased ET. RESULTS: 813/1636(49.7%) of the original female cohort attended follow-up; ET was measured in 567(69.7%). Median (IQR) age of females was 61 (56-66) years. 323 fulfilled criteria for MetS (prevalence 57.1%) in 2007. 57(10.1%) had increased ET in 2014. Increasing plasma triglycerides [OR=1.004 per mg/dl, 95%CI:1.001-1.007, p<0.05] and being hypertensive [OR=2.16, 95%CI:1.11–4.08, p<0.05] were associated with increased ET, while advancing age [OR=0.93 per year, 95%CI:0.89–0.98, p<0.01] and being diabetic [OR= 0.34, 95%CI:0.10–0.89, p<0.05] were protective. CONCLUSIONS: Hypertension and increased plasma triglyceride levels, in the pre-menopausal period, were risk factors for future asymptomatic increased ET.