Conference Papers
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This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine
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Item Effect of mebendazole threapy in pregnancy on birth outcome(Sri Lanka Medical Association, 1998) de Silva, N.; Sirisena, J.; Gunasekera, D.; de Silva, J.OBJECTIVES : A prospective, unmatched, case-control study was done to assess the safety of mebendazole threapy in pregnancy, a hitherto uninvestigated factor. DESIGN : All women delivering in the University Obstetrics Unit of the Ragama Teaching Hospital between May 1996 and, March 1997 were administered a questionnaire soon after delivery. Details of the birth and the baby were recorded; suspected defects were confirmed by a paediatrician. The incidence of congenital defects in babies of mothers who had taken mebendazole during the pregnancy was compared with the incidence among those who had not taken an anthelmintic (controls). Data analysis was done using Epi Info 6.03. RESULTS : Of 3688 women, 73.5% had taken mebendazole, 24.8% had not taken any any anthelmintic , 1.1% had taken an anthelmintic but could not identify it and 0.6% had taken pyrantel or albedazole. The incidence of birth defects was 2.36% {64/2711) in the mebendazole group compared with 2.3% (21/913) in the controls (odds ratio 1.03, 95% confidence limits 0.61 - 1.75). This difference was not statistically significant even when corrected for other known risk factors by stratified analysis . Data regarding timing of mebendazole threapy was available for 2660 women; 6.9% in the first trimester, 83.8% in the second, and 9.2% in the third. The incidence of birth defects among women who had taken mebendazole in the first trimester was 3.24% (6/185). giving an odds ratio of 1.42 against the controls; this was also not statistically significant.CONCLUSIONS : The use of mebendazole in pregnancy does not lead to a significant increase in the risk of congenital defects.Item Does Sanders-Retzlaff-Kraff (SRK-2) formula suit a Sri Lankan population in phacoemulsification cataract surgery of medium axial length?(Sri Lanka Medical Association, 2012) Amaratunge, M.S.; de Silva, J.; Wasthuhewaarachchi, I.M.; Uyangoda, S.H.; Mallawaarachchi, M.A.J.I.; Premaratna, R.; Nishad, A.A.N.INTRODUCTION: After introduction of phacoemulsification with small incision techniques, intraocular lens (IOL) power calculation predictionhas become a crucial step for good refractive outcomes. SRK-2 formula is widely used for that purpose in many locations. AIMS: To evaluate the predictive accuracy of post operative refraction using SRK-2 formula in phacoemulsification of eyes with 22-26mm axial length. METHODS: Patients with senile cataracts undergoing phacoemulsification and IOL during 2011 in Gampaha district by a single surgeon were selected randomly. Single examiner measured simulated manual keratometry preoperatively, seven days postoperatively. Uncorrected visual acuity, slit lamp examination of anterior segment and best spectacle-corrected visual acuity (BSCVA) were measured. The implanted IOL power was used to calculate the predicted postoperative refractive error using time SRK-2 formula. RESULTS: Of 274 patients (56% females, mean (SD) age 65.3(10) years), the right eye was operated in 142(51.8%). On postoperative seventh day, 79% had VA of 6/6 and 14% to 6/9, 4% to 6/12 to 6/36 in the operated eye. Mean (SD) of IOL power used 21.50 (1.90)D. The predicted refractive error with SRK-2 was -0.3(0.145)0 and the achieved refractive error was -0.22(0.732)0. Difference between predicted and achieved refractive error presented a slight hyperopic shift (mean(SD) 0.054(0.397)0}. There was a negative Pearson correlation (-0.126) between the predicted refractive error and achieved refractive error (p=0.04). Predictive error was less than 0.5 in 80.2%, <0.75 in 88.6% and <1.0 in 96.7%. CONCLUSIONS: SRK-2 formula is a good option to predict the refractive error after cataract extraction by phacoemulsification in eyes with medium axial length.Item Prevalence of diabetes mellitus and hypertension among three populations with cataract in Vavuniya and Gampaha districts in the post conflict era(Sri Lanka Medical Assosiation, 2012) Amaratunge, M.S.; de Silva, J.; Wasthuhewaarachchi, I.M.; Uyangoda, S.H.; Mallawaarachchi, M.A.J.; Premaratna, R.; Nishad, A.A.N.INTRODUCTION: Identification of socio economic factors and non communicable disease profiles of patients with cataract is important to plan vision related health services. AIMS: To compare prevalence of diabetes mellitus [DM] and hypertension (HT) among three groups of cataract patients. METHODS: Prevalence of diabetes-and hypertension was compared in groups of patients with cataracts during second quarter of 2011. Group A: a rural population in Vavuniya, B: semi-urban low socioeconomic group and C: semi-urban higher socioeconomic group in Gampaha. Standard criteria used to detect diabetes and hypertension. RESULTS: Population in A 167(36% males), B 207(62% males) and C 407(40% males). Mean (SD) age was 65(10) years. Male diabetes prevalence (95% CI) were A 20% (9.3-28), B 30%(22.6-38.4) and C 37.9%(30.8-45.6) (p=0.009). Prevalence (95%CI) of diabetes in females were A 17.8% (11.7-26), B 19% (11.9-29) and C 33.7% (28.1-39.9) (p=0.002). Hypertension prevalence in males (95%CI) A 23.3% (15- 35.4), B 35.4% (27.6-44) and C 36-6% (29.6-44.3) (>=0.16) a"d in females A 26.2% (18.8-35.2), B 15.2% (9-24.7) and C 45.1% (39-51.4) (p=0.001). Prevalence of either diabetes or hypertension among males A 31.7% (21-44), B 54.3% (45.7-62.7) and C 56% (48.2-63.3) (p=0.001) and among females A 34.6% (26- 44), B 26.6% (18-37.2) and C 57.8% (51,5-63.7) (p=0.001). Conclusions: Females in higher socioeconomic group of Gampaha district had higher diabetes and hypertension prevalence than in lower socioeconomic populations. Male groups showed same pattern for diabetes but not for hypertension. Overall prevalence of hypertension and diabetes mellitus were higher than for general population in Sri Lanka.