Conference Papers

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This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine

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Comparison of urban diabetics with optimal and suboptimal control
(British Medical Association, London, 2011) Pinidiyapathirage, M.; Warnakulasuriya, T.; Kasturiratne, A.; Ranawaka, U.; Gunasekera, D.; Wijekoon, N.; Medagoda, K.; Perera, S.; Takeuchi, F.; Kato, N.; Wickremasinghe, A.R.
Introduction The prevalence of Diabetes Mellitus in Sri Lanka is increasing. We describe the characteristics of patients with optimal and suboptimal control of diabetes among known diabetics in a 35–64-year-old urban population resident in the Ragama Medical Officer of Health (Ragama MOH) area of Sri Lanka. Methods A cross sectional study was conducted among 2986 randomly selected 35–64 year olds in the Ragama MOH area from January to September 2007. A detailed history was taken and participants were subjected to a physical examination and assay of fasting blood glucose and HbA1C. A HBA1C <6.5 was taken as evidence of optimal control. Results There were 474 persons (194 males and 280 females) who gave a past history of diabetes. 9 males and 9 females were not on any treatment. 27 persons (9 males and 18 females) were on insulin. Of the 474 diabetics, 113 (48 males and 65 females) had a HbA1c <6.5. The average fasting blood glucose of diabetics with optimal control was 120+21 mg/dl. The mean fasting blood glucose level of the 361 subjects with sub optimal control was 190+70 mg/dl. Optimal glycaemic control was not associated with alcohol intake, smoking, obesity, central obesity and low physical activity levels. Conclusions Most known diabetics had access to treatment but only approximately 25% were optimally treated. The need to optimally manage these patients is highlighted.
Variation of segment specific carotid artery intima-media thickness in a selected Sri Lankan population.
(Sri Lanka Medical Association, 2021) Abeysuriya, V.; Wijesinha, A.N.I.; Priyadharshan, A.; Wickremasinghe, A.R.
Introduction and objective Carotid artery intima-media thickness (CIMT) is a strong predictor of coronary heart disease (CHD). The literature debates considering segment-specific CIMT variation while constructing country-specific risk prediction models to screen at-risk populations. We evaluated segment-and site-specific variation in CIMT to derive a composite score for Sri Lankans. Methods The study was conducted from November 2019 to October 2020 in a private hospital in Colombo. Based on predefined inclusion-exclusion criteria, cases (having a CHD diagnosis, n=338) and controls (n=356) were recruited. People without any suggestive medical history of having angina type chest pain , no significant ECG changes suggestive of acute coronary syndrome, negative treadmill test, normal echocardiographic evidence and negative test results of Troponin I and T were considered as controls. Ultrasound examination of the common-carotid-(CCA), the carotid-bulb-(CB) and the internalcarotid segments-(ICA) of the carotid vessel were conducted by a radiologist, and CIMTs were measured. A composite-CIMT score defined as the average value of all six segments of both the left and right sides was derived. Results 694 participants were enrolled. The mean-(+SD) age of the study sample was 60.2(±9.86) years. The highest mean-(+SD) CIMT value was in the CB-(0.89 (±0.09mm)) in the CHD group and in the CCA-(0.72 (±0.11mm)) in the non-CHD group. The lowest mean-(+SD) CIMT was in the ICA in both the CHD group-(0.86 (±0.08mm)) and in the non-CHD-(0.69 (±0.11mm)). There was a significant difference in the mean CIMT values between the right and left sides (p<0.05 for all) in both the two groups. The composite value for CHD and non-CHD groups was 0.88(±0.07) mm and 0.71(±0.09) mm (P<0.001). Conclusion Carotid artery segment-specific-CIMT variations are present in this population. Further analyses should be carried out to determine if a composite-CIMT value is a better predictor of CHD.
It’s normal to drink, isn’t it? a qualitative study on factors influencing adolescent drinking in Sri Lanka
(Sri Lanka Medical Association, 2021) Athauda, L.K.; Pereis-John, R.; McCool, J.; Ameratunga, S.; Wickremasinghe, A.R.
Introduction and Objectives In Sri Lanka, adolescent drinking behaviour has been linked to parental, family influence as well as culture and living location. While proximal level social determinants play an important part in influencing adolescent drinking, determinants operating at the distal level have not been discussed adequately. This study aimed to describe the factors influencing adolescent drinking among school going adolescents in the Colombo District. Methods Focus Group Discussions (FGD) were conducted separately for males and females in selected Public Health Midwife (PHM) areas in the Colombo District. A semi structured interview guide facilitated the discussion. Transcripts were translated, transcribed and managed on NVivo 12. Inductive thematic analysis was used to interpret the ideas expressed in the FGDs. Results Fifty adolescents (24 females and 26 males) aged between 16-17 years participated in eight FGDSs. The findings elaborate one overarching theme: it’s normal to drink, isn’t it? Media, culture and society contributed towards building social norms around adolescent drinking. Based on the perception of normalcy around drinking, adolescents were inclined to test their limits and experiment with alcohol, while being influenced by peers. However, they also experienced some restraints, in terms of law, family and culture, which made them question the normalcy around drinking. Conclusion Adolescents engage in social learning, through their distal environment which creates norms and aspirations. Peer engagement facilitates social capital which also contributes towards their decisions to drink. Distal level social determinants are important contributory factors of adolescent alcohol use. Restrictions within this environment may restrict their drinking
Prevalence, predictors and outcome of chronic kidney disease in a cohort of aging urban, adult Sri Lankans
(Sri Lanka Medical Association, 2021) de Silva, S.T.; Ediriweera, D.D.; Niriella, M.A.; Kasturiratne, A.; Kato, N.; Wickremasinghe, A.R.; de Silva, H.J.
Introduction and Objectives Chronic kidney disease (CKD) affects 700 million people worldwide. In 2017, deaths due to CKD accounted for 4.6% of mortality globally. Prevalence of CKD is increasing worldwide, with increasing diabetes and hypertension in aging populations. Our objective was to determine prevalence of CKD in an urban, adult cohort, since such data is scarce in Sri Lanka. Methods The study population was selected by stratified random sampling from Ragama MOH area initially in 2007 (aged 35-64 years) and re-assessed in 2014. On both occasions, participants were assessed by structured interview, anthropometric measurements and biochemical tests. CKD was assessed in 2014. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI formula. CKD was defined as eGFR<60ml/min/1.72m2, using KDIGO/KDOQI classification. The cohort was further followed up in 2017 when all-cause and cardiovascular (CV) mortality and CV morbidity were also assessed. Results Of 2985 individuals recruited in 2007, 2148(71.6%) attended follow-up in 2014. 2032/2148 (94.6%) had CKD data [57.0% women, mean age 52.3(SD 7.7) years]. Age adjusted prevalence of CKD was 3.03(1.98–4.11) per 100 population in 2014; 41/61(67.2%) were in CKD Stage-3A, 14/61(23%) in Stage-3B, 6/61(9.8%) in Stage-4 and none in end-stage. Independent predictors of CKD in 2014 were older age (p<0.001), male gender (P<0.05) and presence of diabetes (p<0.001) and hypertension (p<0,001) in 2007. CKD was not associated with all-cause mortality, CV mortality or morbidity (p>0.05) in 2017.Conclusion Diabetes and hypertension were associated with CKD. Most with CKD were in Stage 3, where early recognition and better control of co-morbidities retard progression of CKD.
Awareness on Malaria among Public and Healthcare Providers during the Prevention of Re-Introduction Phase in Sri Lanka
(Sri Lanka Medical Association, 2020) Hamsananthy, J.; Wickremasinghe, A.R.
INTRODUCTION AND OBJECTIVES: Prevention of re-introduction/re-establishment of malaria is a challenge for Sri Lanka due to high receptivity and vulnerability. Imported cases are being reported and an introduced case was reported in 2018. The objective of this study was to assess the awareness on malaria among public and healthcare providers which is essential during the prevention of re-introduction/re-establishment phase. METHODOLOGY: Two national surveys were conducted among 3454 households and 766 healthcare providers in 2016. Household survey was conducted using a multistage cluster sampling method. Healthcare providers’ survey used stratified random sampling and a self-administered questionnaire. RESULTS: The mean awareness score of healthcare providers was 54.7% (SD=10.6). Although 99.1% of healthcare providers (n=759) identified fever as a symptom of malaria, the majority (n=634) had not seen, diagnosed or treated a malaria case during the last 5 years. The mean awareness score of heads of households was 28.6 % (SD = 9.03). 74.4% of heads of households (n=2570) had ever seen/heard messages about malaria; 7.2% (n=249) had seen/heard in the past 6 months. The common media of communication were television (n=2714, 78.6%) and mobile phones (n=2242, 64.9%). The majority knew that malaria is spread by a mosquito bite (92.7%, n=3202) and fever (71.8% n=2479) is a symptom of malaria. CONCLUSIONS: The majority of healthcare providers have not seen a case of malaria; updates on malaria should be regularly given to suspect malaria in the differential diagnosis of fever. Television and mobile phone technology can be used to increase awareness on malaria among the general public.
Randomized Controlled Trial Investigating the Effectiveness of Cognitive Behaviour Group Therapy Compared to a Waitlist Control in the Treatment of University Students with Social Phobia
(Sri Lanka Medical Association, 2020) Hapangama, A.; de Silva, B.G.R.; de Zoysa, P.T.; Kuruppuarachchi, K.A.L.A.; Ravindran, A.; Wickremasinghe, A.R.; Williams, S.S.
INTRODUCTION AND OBJECTIVES: Social phobia causes significant impairment in a person’s personal and professional life. However, individually delivered cognitive behavioural therapy (CBT) is costly, limited by the number of trained therapists and not scalable to meet the need for such therapy in the population. In this context, cognitive behavioral group therapy (CBGT) is the viable option. Objective was to determine the treatment effectiveness of CBGT as compared to a waitlist control of university students with social phobia. METHOD: A single-blind randomized controlled trial consisting of an 8-week treatment phase of CBGT versus a waitlist control was conducted among university students with social phobia. The Liebowitz Social Anxiety Scale –Self Rated Sinhala version (LSAS-SR) was administered at screening, baseline, four weeks and eight weeks of the trial. A culturally adapted CBGT was delivered in Sinhala to the intervention group by a trained clinical psychologist. RESULTS: Thirty university students (15 in each arm) with a mean age of 22, meeting DSM IV criteria for Social Anxiety Disorder were included. Repeated measure analysis of the total scores of the LSAS-SR in the CBGT arm showed statistically significant (p<0.001) reduction in the total scores (13.3) as compared to the waitlist arm after controlling for age and gender. CONCLUSION: CBGT is superior to waitlist control in university students with social phobia.
Introduction of a Safe Water System (SWS) In a tsunami attuned community In Hikkaduwa, Sri Lanka
(College of the Community Physicians of Sri Lanka, 2007) Pinidiyapathirage, M.J.; Wijeyaratnez, P.; Wickremasinghe, A.R.; Kalluri, P.
INTRODUCTION: The SWS is an intervention that employs simple, robust, and inexpensive technologies to make drinking water safe at the point oi use through disinfection and safe storage. OBJECTIVE: To introduce a sale water system using household chlorination and washing of hands with soap in the community. METHODS: A commercially prepared solution of 0.9% sodium hypochlorite ('Chlovathura') in 130ml plastic bottles and a 20-liter plastic container with a narrow mouth and a lid was provided tree 01 charge. Trained community assistants distributed and promoted the use of the SWS using interpersonal communication methods. Hand washing using soap was promoted simultaneously. Surveys were conducted at baseline (n=452). six months (n=100) and 18 months (n=200) post- intervention to assess use. RESULTS: All were aware of the product ’Chlovathura' by six months of its introduction. 0t those who were aware oi the product, 49% (n=98) correctly described how it should be used at baseline and this percentage improved to 75% (n=149) post-intervention. When stored water at household level was tested for chlorine, it was present in the specified concentration in 6% 01:26), 27% (n=27) and 34% (n=67) at baseline, six months and 18 months respectively. The incidence of a diarrhoeal episode within the past two weeks among children under 5 years in the sample reduced to 4.8% (n=4) at 18 months from 5.4% (n=8) at baseline (p>0.05). CONCLUSION: The SWS was accepted and correctly practiced by more than one third of the target population. The SWS can be promoted in other areas with remote access to safe drinking water and may be a solution to reduce the morbidity due to diarrhoeal diseases in the country.
Validation of the World Health Organization/ International Society of Hypertension (WHO/ISH) cardiovascular risk predictions in Sri Lankans based on findings from a prospective cohort study
(Ceylon College of Physicians, 2020) Thulani, U.B.; Mettananda, K.C.D.; Warnakulasuriya, D.T.D.; Peiris, T.S.G.; Kasturiratne, K.T.A.A.; Ranawaka, U.K.; Chackrewarthy, S.; Dassanayake, A.S.; Kurukulasooriya, S.A.F.; Niriella, M.A.; de Silva, S.T.; Pathmeswaran, A.P.; Kato, N.; de Silva, H.J.; Wickremasinghe, A.R.
INTRODUCTION AND OBJECTIVES: There are no cardiovascular(CV)-risk prediction models specifically for Sri Lankans. Different risk prediction models not validated among Sri Lankans are being used to predict CV-risk of Sri Lankans. We validated the WHO/ISH (SEAR-B) risk prediction charts prospectively in a population-based cohort of Sri Lankans. METHOD: We selected participants between 40-64 years, by stratified random sampling of the Ragama Medical Officer of Health area in 2007 and followed them up for 10-years. Risk predictions for 10-years were calculated using WHO/ISH (SEAR-B) charts with- and without-cholesterol in 2007. We identified all new-onset cardiovascular events(CVE) from 2007-2017 by interviewing participants and perusing medical-records/death-certificates in 2017. We validated the risk predictions against observed CVEs. RESULTS: Baseline cohort consisted of 2517 participants (males 1132 (45%), mean age 53.7 (SD: 6.7 years). We observed 215 (8.6%) CVEs over 10-years. WHO/ISH (SEAR B) charts with and without-cholesterol predicted 9.3% (235/2517) and 4.2% (106/2517) to be of high CV-risk ≥20%), respectively. Risk predictions of both WHO/ISH (SEAR B) charts with- and without-cholesterol were in agreement in 2033/2517 (80.3%). Risk predictions of WHO/ISH (SEAR B) charts with and with out-cholesterol were in agreement with observed CVE percentages among all except in high risk females predicted by WHO/ISH (SEAR B) chart with-cholesterol (observed risk 15.3% (95% Cl 12.5 - 18.2%) and predicted risk 2::20%). CONCLUSIONS: WHO/ISH (SEAR B) risk charts provide good 10-year CV-risk predictions for Sri Lankans. The predictions of the two charts, with and without-cholesterol, appear to be in agreement but the chart with-cholesterol seems to be more predictive than the chart without-cholesterol. Risk charts are more predictive in males than in females. The predictive accuracy was best when stratified into two categories; low (<20%) and high (≥20%) risk.
Incidence and prevalence of stroke and time trends in vascular risk factors among urban/semi-urban Sri Lankans: A population-based cohort study
(Ceylon College of Physicians, 2020) Mettananda, K.C.D.; Ranawaka, U.K.; Wickramarathna, K.B.; Kottahachchi, D.C.; Kurukulasuriya, S.A.F.; Matha, M.B.C.; Dassanayake, A.S.; Kasturiratne, K.T.A.A.; Pathmeswaran, A.; Wickremasinghe, A.R.; de Silva, H.J.
INTRODUCTION AND OBJECTIVES: Incidence of stroke is declining in developed countries, but is increasing in developing countries. There is no data on incidence of stroke in Sri Lanka, and only limited data on prevalence of stroke. METHODS: We studied a population-based cohort (35-64 years) selected by stratified random sampling from an urban/semi-urban health administrative area (Ragama Health Study) in 2007, and evaluated them again in 2014 with regard to new onset stroke and prevalence of vascular risk factors. Possible stroke patients were independently reviewed by a neurologist and a physician with regard to the diagnosis of stroke. The prevalence of stroke (at baseline) was estimated. Prevalence of vascular risk factors in the population were compared between 2007 and 2014. RESULTS: The baseline cohort in 2007 consisted of 2985 individuals (females 54.5%, mean age 52.4 ± 7.8 years). Of them, 2204 attended follow-up in 2014 (female 57.6%, mean age 59.2±7.6 years). 19 had a history of strokes at enrolment (stroke prevalence 6.37/1000 population) and 24 episodes of strokes occurred over the 7 years (annual incidence of stroke 1.56/1000 population). Risk factor prevalence in 2007 and 2014 were; hypertension 48.7% and 64.3%; hyperlipidaemia 35.5% and 39.3%; diabetes mellitus 28.2% and 35.7%; and obesity 2.6% and 17.9%, respectively. CONCLUSION: Stroke incidence and prevalence rates of Sri Lanka lie between those of developed and developing countries. Prevalence of vascular risks have increased over time in this urban/semi urban Sri Lankan population.
Adaptation of "Medical Interview Satisfaction Scale" (MISS-21) for Sri Lankan general practice
(Sri Lanka Medical Association, 2019) de Silva, A.H.W.; Kasturiratne, K.T.A.A.; Seneviratne, A.L.P.; Wickremasinghe, A.R.
INTRODUCTION & OBJECTIVES: Patient satisfaction is an important clinical outcome and a validated Sinhalese tool to measure it is essential. MISS 21 is a tool validated in the British general practice. Objective was to translate, cross-culturally adapt and validate the MISS 21 to for the Sri Lankan Sinhala speaking general practice setting. METHODS: The suitability and relevance of items in MISS-21 were assessed and unacceptable items revised. Translation process involved back translations and synthesis. Conceptual and linguistic equivalence was considered. Accuracy in rephrasing-and semantic adjustments was made following pretest. Operational equivalence was evaluated. A sample size of 300 was estimated and 480 recruited to account for non-respondents. Tool was self-administered amongst literate Sinhala patients of ≥18 years from six general practices. Exploratory factor analysis (EFA) extracted potential components associated with satisfaction. Internal consistency was assessed using Cronbach's alpha. RESULTS: Sixteen items fulfilled 80% acceptance. Four items were retained unchanged on consensus while one item was changed. Operational equivalence was accepted. Only 381 were complete enabling EFA. EFA extracted two components. This model explained 56% of the variability of total patient satisfaction scores. Items exploring communication and distress releasing aspects loaded on component 1 ("communication and comfort"). Items related to unmet expectations of patients and the doctor's regard loaded on component 2 ("regard and clarity"). All items in components 1 and 2 (Cronbach's alpha >0.9 and >0.7) demonstrated good internal consistency. CONCLUSION: The Sinhala version of MISS 21 exhibited high content validity, satisfactory construct validity with an acceptable factor structure, internal consistency and high response rates.

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