Conference Papers

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This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine

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2007 - 200912010 - 20121

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Author: search.filters.author.Thoradeniya, T.

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    Influence of baseline inflammatory status on dietary effects of nutrition counseling in women with and without coronary artery disease
    (Sri Lanka Medical Association, 2012) Thoradeniya, T.; Senenayake, C.; Wickremasinghe, R.; Mendis, S.; Jayasena, S.; Atukorala, S.
    INTRODUCTION: Inflammatory status influences the biochemical response to diet, suggesting an additional mechanism increasing coronary artery disease (CAD) risk. Aims: To determine the effect of baseline inflammatory status on biochemical response to nutrition counseling to reduce CAD risk. METHODS: A 2x2 factorial experiment having an intervention was conducted among 40-60 year old women with (n=101) and without CAD (n=109). Intervention comprised nutrition counseling. Baseline and post-intervention data on diet, serum high sensitivity CRP (hsCRP), soluble ICAM-1 (sICAM-1), ferritin, folate, plasma total homocysteine (tHcy) concentrations and traditional CAD risk factors were assessed. RESULTS: At baseline tHcy, sICAM-1 and hsCRP concentrations were significantly higher (p<0.05) among women with CAD than in women without CAD. Baseline sICAM-1 [OR=3.19 (95"% CI, 1.65-6.17)] and tHcy concentrations [OR=1.33 (95% CI 1.1-1.61)] were independently associated with CAD after adjusting for other risk factors. Nutrition counseling significantly decreased serum total and LDL cholesterol and increased serum folate (p<0.05) in women without CAD, but not in women with CAD. Among women without CAD, nutrition counseling decreased serum total and LDL cholesterol, and increased serum folate (p<0.05) in the "low" hsCRP group (below median of controls) but not in the "high" hsCRP group (above median). CONCLUSIONS: Nutrition counseling was effective in reducing serum total and LDL cholesterol and increasing serum folate in women without CAD having a "low" baseline inflammatory status. The hindering effect of underlying inflammation, on the biochemical response to dietary modification should be considered in dietary interventions in CAD risk reduction.
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    Hyperhomocysteinaemia among adolescent girls and young women
    (Sri Lanka Medical Association, 2007) Thoradeniya, T.; Atukorala, S.; Wickremasinghe, R.
    INTRODUCTION: Moderately elevated plasma total homocysteine (tHcy) is an independent risk factor for adverse pregnancy outcomes and cardiovascular disease in women. OBJECTIVE: To determine the prevalence of hyperhomocysteinaemia and its association with serum folate and vitamin Bi2 concentrations, BMI and waist circumference (indicators of general nutritional status and cardiovascular risk factors) among adolescent girls and young women. DESIGN, SETTING AND METHODS: A sample of 552 adolescent girls aged 15-18.9 years (n=277) and young women aged 19-30 years (n=275) from Colombo municipality were randomly selected for a study conducted on low folate status and anaemia. A sub-sample with tHcy data was selected for the present study (adolescent girls: n=123; young women: n=136). Serum folate and vitamin B,2 were measured. Anthropometric data were obtained and body mass index (BMI) was calculated. RESULTS: Hyperhomocysteinaemia (tHcy>15 umol/L) was observed among 18.9% of subjects (adolescent girls: 19.5% and young women: 18.4%). Though a high prevalence was noted (43.0%) for low folate status (serum folate <3 ng/ml), none of the subjects studied bad serum vitamin B12 <150 pg/ml. Inverse correlations were noted between tHcy and serum folate (r=-0.151, P=0.018) and vitamin B12 ,r=-0.202, P=0.004) concentrations. Interestingly, positive correlations were noted among tHcy and BMI (r=0.168, P=0.007) and waist circumference (r=0.145, P=0.019). CONCLUSIONS: Our results suggest that hyperhomocysteinaemia could be partly attributable to low folate and vitamin B12 status. The associations noted between tHcy and BMI and waist circumference warrants further investigations in relation to food intake and disease outcomes in this population. ACKNOWLEDGEMENT: Financial support: IAEA, Vienna