Conference Papers

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This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine

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Author: search.filters.author.Ranaweera, L.

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    Anthropometric knee profile measurements on articulator surface of femur among Sri Lankan population.
    (Sri Lanka Medical Association, 2023) Fernando, G.K.S.; Ranaweera, L.; Cabral, L.L.E.; Dissanayaka, P.; Bandara, I.D.M.R.N.; Sovis, W.F.U.N.
    INTRODUCTION: In Sri Lankan context there are no published data for articulator surface measurements for knee joints. Forensic, Anatomical, Archaeological, Bio-medical engineering, development of knee S145 prosthesis beneficial with anthropometrics. Digital Vernier Caliper (measuring range 0-140mm, resolution 0.02mm, accuracy ±0.01mm) used to obtain measurements. OBJECTIVES: The aim of this study, was to provide standard anthropometrics for the distal femur in Sri Lankan context. METHODS: Dried adult Femurs (42 male and 28 female) were analysed for the measurements of Medial condyle Antero-Postero Length (MAP), Anteroposterior length of intercondylar area (AP), Medial-Lateral Length (ML), Aspect Ratio (ML/AP) and Epi Condylar breadth (EB). Sex Dimorphism Ratio (SDR) were calculated for dry femurs. RESULTS: The mean values for male; MAP 24.95(±2.22), AP 25.47(±2.27), ML 20.82(±2.56), Aspect Ratio 0.82(±0.11) and EB 7.68(±0.43). The mean values for female; MAP 24.95(±3.08), AP 25.47(±3.16), ML 20.82(±2.28), Aspect Ratio 0.82(±0.18) and EB 7.68(±0.37). SDR values are MAP 107.74, AP 107.12, ML 99.04, and EB 106.55. CONCLUSIONS: The majority of SDR values lie above 100. Therefore, a difference between male and female values can be observed. Findings offer assistance to develop knee joint prostheses with culture-particular values, fitting for the Sri Lankan setting and pave the pathway to the studies on the above-mentioned fields in the local and international context. Sex determination is a crucial element in the creation of a biological profile since it offers information for identities.
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    Identification of type 2 diabetes patients with non-alcoholic fatty liver disease who are at increased risk of significant hepatic fibrosis: a cross-sectional study
    (Sri Lanka Medical Association, 2023) Mettananda, K.C.D.; Egodage, T.; Dantanarayana, C.; Solangarachchi, M.B.; Fernando, R.; Ranaweera, L.; Siriwardhena, S.; Ranawaka, C.K.; Kottahachchi, D.; Pathmeswaran, A.; Dassanayake, A.S.; de Silva, H.J.
    INTRODUCTION: Annual screening of patients with diabetes for fatty liver, and identifying those with significant hepatic fibrosis using the FIB-4 score and vibration-controlled transient elastography (VCTE) has been recommended to detect patients who may progress to advanced hepatic fibrosis/cirrhosis. However, VCTE is not freely available in resource-limited settings. OBJECTIVES: To identify clinical and biochemical predictors of significant liver fibrosis in diabetics with fatty liver. METHODS: We conducted a cross-sectional study among all consenting adults with T2DM and non-alcoholic fatty liver disease (NAFLD) attending the Colombo North Teaching Hospital, Ragama, Sri Lanka from November 2021 to November 2022. FIB-4 scores were calculated and patients with a score ≥1.3 underwent VCTE. Risk associations for liver fibrosis were identified by comparing patients with significant fibrosis (LSM ≥8 kPa) with those without significant fibrosis (FIB-4<1.3). RESULTS: A total of 363 persons were investigated. Of these, 243 had a score of FIB-4 <1.3. Of the 120 with a FIB-4 ≥1.3, 76 had LSM ≥8 kPa. Significant fibrosis was individually associated with age (OR 1.01, p<0.0001), duration of diabetes (OR 1.02, p=0.006), family history of liver disease (OR 1.42, p=0.035), waist (OR 1.04, p=0.035), and FIB-4 (OR 2.08, p<0.0001). However, on adjusted analysis, significant fibrosis was only associated with a family history of liver disease (OR 2.69, p=0.044) and FIB-4 (OR 1.43, p<0.001). CONCLUSION: In patients with T2DM and fatty liver, advancing age, increased duration of diabetes, a family history of liver disease, waist circumference and a high FIB-4 score increase the risk of significant hepatic fibrosis. Targeted interventions in this group may help prevent progression to advanced hepatic fibrosis/cirrhosis.