Conference Papers
Permanent URI for this collectionhttp://repository.kln.ac.lk/handle/123456789/6561
This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine
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Item The presence of strongyloidiasis and associated risk factors in patients undergoing treatment at the National Cancer Institute, Maharagama, Sri Lanka(Sri Lanka Medical Association, 2023) Weerasekera, C.J.; Menike, C.W.; Wimalasiri, U.; Wijerathna, T.; Jayathilake, D.C.C.; Somawardane, U.A.B.P.; Saravanamuttu, U.; Yoganathan, N.; Perera, N.; Gunathilaka, N.; de Silva, N.R.; Wickremasinghe, D.R.INTRODUCTION: Strongyloides stercoralis can cause severe disease in the immunocompromised. Without a proper gold-standard diagnostic technique, strongyloidiasis is scarcely studied both globally and locally. OBJECTIVES: We aimed to estimate the prevalence of strongyloidiasis among immunocompromised adult patients and to identify risk factors. METHODS: This study was carried out between February to October 2022. A faecal sample and 2 ml of venous blood were collected from consented patients. Direct faecal smear, agar plate, Harada-Mori and Charcoal cultures were performed on the faecal samples. Qualitative Polymerase Chain Reaction (PCR) was performed on selected faecal samples using S. stercoralis targeting ITS1 region. Strongyloides IgG ELISA was carried out on the serum samples using DRG Strongyloides IgG ELISA kit. RESULTS: Collectively, 144 patients (males = 68, females = 76) provided blood/faecal sample or both. Relevant to strongyloidiasis-associated symptoms, some patients had diarrhoea (n=12) and eosinophilia (n=11). Some of them (n=74) had occupational or recreational exposure to soil as potential risk factors. Overall, 24 patients were positive for strongyloidiasis from one or more diagnostic method (5 PCR and 19 ELISA). There were zero culture or direct smear positives. There was no significant association between disease positivity with either of the clinical features or risk factors. CONCLUSION: The prevalence of strongyloidiasis in patients with malignancies was 16.66%. Strongyloidiasis is existent in the immunocompromised in Sri Lanka even in the absence of suggestive clinical features or regular exposure to risk factors. Screening immunocompromised patients with sensitive techniques such as PCR for timely diagnosis and treatment is recommended.Item Risk factors for Pregnancy induced Hypertension(College of the Community Physicians of Sri Lanka, 2007) Perera, N.; Abeysena, C.OBJECTIVE: TO determine the risk factors for pregnancy induced hypertension (PIH). METHODOLOGY: The study was a case control study which was carried out at Castle Street Hospital for Women during August to September 2006. Hundred mothers newly diagnosed as having PlH. were Chosen as cases and 100 with uncomplicated pregnancies as controls. Both cases and controls had a period of amenorrhoea of >20 weeks. Psychosocial Stress was measured using General Health Questionnaire -30 (GHQ) and Modified Life Event inventory. Maternal socio-demographic information and other data were collected using an interviewer administered questionnaire and a record sheet. Multivariate logistic regression analysis was applied to control for confounders and the results were expressed as odds ratios (OR) and 95% confidence intervals (95%Cl). RESULTS: After adjusting for confounding effect experience of ≥2 life events during pregnancy (OR:2.1, 95%Cl:1.1 - 10.9), a maternal BMl of ≥26kg/m2 (OR:2.4, 95%Cl:1.1- 5.0), maternal age of ≥28 years (OR:3.9, 95%Cl:2.0-7.5), history of ante partum haemorrhage (OR:3.4, 95%Clz1.1 - 10.9) and standing for >1.5 hours at one stretch per day (OR:3.4, 95%Cl:1.6 - 7.4) had statistically significant associations with developing PlH. A GHQ score of >5 was not associated with PlH (OR:3.0, 95%Cl: 1.0 -10.0). CONCLUSION: Experience of 22 life events during pregnancy, BMl ≥26 kg/m2, maternal age of ≥28 years, history of antepartum haemoghage and standing for more than 1.5 hours at one stretch per day were risk factors for PlH.