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Browsing by Author "Premawardhena, A.P."

Browsing by Author "Premawardhena, A.P."

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  • 20 year follow up and survival analysis in a cohort of patients with Haemoglobin E beta Thalassaemia. 
    Olivieri, N.F.; Premawardhena, A.P.; Amir-Arsalan, S.; Ediriweera, D.; Mettananda, S.; Bandara, W.D.; Arambepola, M.; de Silva, S.; Refai, M.A.C.M.; Allen, A. (Sri Lanka Medical Association., 2019)
    INTRODUCTION & OBJECTIVES: Haemoglobin E beta thalassaemia (EBT) is the commonest beta thalassaemia syndrome in the world and is extremely phenotypically variable. Unlike for transfusion dependent thalassaemia (TDT) there ...
  • Anemia in Sri Lanka: A literature review 
    Amarasingha, A.A.D.S.; Silva, H.J.R.L.; Perera, P.S.; Premawardhena, A.P. (Informa Healthcare, 2022)
    Anemia is a global health problem. This paper reviews literature on the prevalence of anemia in Sri Lanka. We searched EBSCO (Elton Bryson Stephens Company), Cochrane Library, and Medline for articles on prevalence and ...
  • Apical cardiomyopathy : an important differential diagnosis in ischaemic chest pain 
    Seneviratne, S.L.; Premawardhena, A.P.; Ranasinghe, G.W.; Gunatilake, S.B.; de Silva, H.J. (Sri Lanka Medical Association, 1996)
    Reports the cases of 1) a 54 year old man admitted with angina like pain of 3 hours. ECG showed deep ngative T waves in the anterolateral leads. But no septal Q waves. 2) a seventy year old man admitted with retrosternal ...
  • Assessing liver fibrosis in patients with transfusion dependent beta thalassaemia - a predictive model 
    Padeniya, A.G.P.M.; Ediriweera, D.; de Silva, A.; Niriella, M.A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2021)
    Introduction and Objectives Liver fibrosis in β-thalassaemia major is mainly due to transfusion-related iron overload. Transient elastography (TE) is an imaging modality which measures liver stiffness/fibrosis non-invasively. ...
  • Assessing reversibility of liver fibrosis in patients with transfusion-dependent beta thalassaemia following intensive chelation 
    Padeniya, A.G.P.M.; Ediriweera, D.; Niriella, M.A.; de Silva, A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2023)
    INTRODUCTION: Transfusion-related iron overload is a leading cause of hepatic fibrosis in transfusion-dependent thalassaemia (TDT). OBJECTIVES: This study aimed to evaluate the reversibility of liver fibrosis with intensive ...
  • Atlanto-axial subluxation:importance of early recognition 
    Gunatilake, S.; Seneviratne, S.L.; Premawardhena, A.P.; de Silva, H.J. (The Kandy Society of Medicine, 1996)
    We report three cases which illustrate the importance of the early recognition of atlanto-axial subluxation by being aware of the disorders it is often associated with.
  • Cardiac functions in older patients with haemoglobin E- β thalassaemia 
    Premawardhena, A.P.; Wanninayake, S.; Dolapihilla, S.N.; Kapuruge, L.; Katugaha, N.; Olivieri, N.F.; Weatherall, D.J. (Sri Lanka Medical Association, 2007)
    INTRODUCTION: Cardiac disease accounts for most deaths in patients with thalassaemia. Little is known about cardiac functions in ageing patients with thalassaemia OBJECTIVE: To study cardiac functions in older patients ...
  • Chracterisation of beta giobin mutations in Sri Lankan patients with betathalassaemia intermedia 
    Perera, S.; Silva, D.P.S.I.; Hapugoda, M.; Wickramarathne, M.N.; Wijesirwardhena, I.; Efremove, D.G.; Fisher, C.A.; Weatherall, D.J.; Premawardhena, A.P. (Sri Lanka Medical Association, 2013)
    INTRODUCTION AND OBJECTIVES: Patients with beta thalassaemia intermedia account for a third of patients attending thalassaemia clinics in Sri Lanka. They show immense phenotypic diversity, the genetic basis for which has ...
  • The clinical effects of excessive a globin genes : two family studies 
    Premawardhena, A.P.; Fisher, C.A.; Rugless, M.; de Silva, S.; Perera, A.W.V.S.; Olivien, N.F.; Weatherall, D.J. (Sri Lanka Medical Association, 2003)
    INTRODUCTION: Globin chain imbalance is the central pathogenic abnormality in the thalassaemias, a condition where globin gene expression is reduced. Conversely, the inheritance of excess globin genes too may affect the ...
  • Coagulopathy and fibrinoloysis following the bite of a hump-nosed viper (Hypnale hypnale) 
    Premawardhena, A.P.; Seneviratne, S.L.; Gunatilake, S.B.; de Silva, H.J. (Oxford University Press, 1996)
    No Abstract Available
  • Cushing syndrome due to an adrenal phaeochromocytoma 
    Gunasekara, A.D.C.J.; Premawardhena, A.P.; Hettiarachchi, H.A.N.S.; Rathnasena, B.G.N.; de Silva, H.J. (Sri Lanka Medical Association, 2006)
    No Abstract Available
  • A descriptive study of anaemia in the elderly at a tertiary care institute in Sri Lanka 
    Chathurangani, K.C.; Darshana, L.G.T.; Premathil, R.A.; Costa, Y.J.; Amarasekara, A.A.D.S.; Premawardhena, A.P. (The Sri Lanka Medical Association, 2022)
    INTRODUCTION: Anaemia is a commonly encountered condition among the elderly population which calls for further evaluation to identify the cause and to prevent complications.OBJECTIVES: To determine the prevalence, causes ...
  • Do thalassaemic patients, their parents and caregivers support termination of pregnancy as a method for thalassaemia prevention? 
    Nandasiri, A.S.D.; Dissakaruna, A.M.D.D.; Silva, D.P.S.I.; Nishad, A.A.N.; Premawardhena, A.P. (Sri Lanka Medical Association, 2011)
    INTRODUCTION AND OBJECTIVES: The only proven way to prevent thalassaemia, the commonest monogenic disease in Sri Lanka, is premarital and ante natal counselling followed by pre-natal diagnosis (PND) and termination of ...
  • Excessive fibrinolysis: the coagulopathy following Merrem's hump-nosed viper( Hypnale hypnale) bites 
    Premawardhena, A.P.; Seneviratne, S.L.; Gunatilake, S.B.; de Silva, H.J. (1998)
    In 56 patients with proven hump-nosed viper (Hypnale hypnale) bites, 12 (21.4 percent) developed continued oozing of blood from the site of the bite and a prolonged clotting time. Further investigations showed low fibrinogen ...
  • Familial thrombocytopaenia in three male siblings 
    Amarasena, P.; Premawardhena, A.P.; Herath, H.R.B.M.; Seneviratne, S.L. (Sri Lanka Medical Association, 2017)
    INTRODUCTION & OBJECTIVES: Familial thrombocytopaenia is uncommon. Specific molecular defects have been identified in some families. We describe three male siblings with thrombocytopaenia and other immune related findings. ...
  • Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia 
    Premawardhena, A.P.; Fisher, C.A.; Fathihu, F.; de Silva, S.; Perera, W.; Peto, T.E.; Olivieri, N.F.; Weatherall, D.J. (2001)
    Chronic hyperbilirubinaemia, gallstone formation, and gall bladder disease are unusually common in people with haemoglobin E beta thalassaemia in Sri Lanka. To determine whether this has a genetic basis we compared the ...
  • Genetic origin and clinical variability of sickle cell disease in Sri Lanka 
    Darshana, L.G.T.; Bandara, W.D.M.S.; Nawaratna, U.S.B.; Costa, Y. J.; Nizri, A.H.M.; Silva, D.P.S. l.; de Silva, T.U.N.; Pushpakumara, K.P.C.; Pathirage, S.P.; Manamperi, A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2018)
    INTRODUCTION AND OBJECTIVES: Sickle cell disease (SCD) is found at a low prevalence In Sri Lanka. A recent hospital based survey identified 60 patients in the country The clinical spectrum of SCD in Sri Lanka ...
  • The Genetic Origins and Molecular Characterization of Sickle Cell Disease in Sri Lanka. 
    Darshana, L.G.T.; Manamperi, A.; Premawardhena, A.P. (In: Proceedings of the International Postgraduate Research Conference 2017 (IPRC – 2017), Faculty of Graduate Studies, University of Kelaniya, Sri Lanka., 2017)
    Sickle cell disease (SCD) is globally the commonest monogenic disease. Although the incidence is not as common as in India, it is found in Sri Lanka too. A recent hospital based survey identified around 60 patients in the ...
  • The Global distribution of length polymorphisms of the promoters of the gucuronosyltransferase I gene(UGTIAI): hematologic and evolutionary implications 
    Premawardhena, A.P.; Fisher, C.A.; Liu, Y.T.; Verma, I.C.; de Silva, S.; Arambepola, M.; Clegg, J.B.; Weatherall, D.J. (Academic Press, 2003)
    The promoter region of the UDP glucuronosyltransferase 1 gene (UGT1A1) contains a run of thymine-adenine (TA) repeats, usually six (TA)(6). As well as its relationship to Gilbert's syndrome, homozygosity for the extended ...
  • HCV and HBV infection among a cohort of Sri Lankan thalassaemic patients 
    Perera, P.S.; Niriella, M.A.; Peries, M.A.C.; Nelumdeniya, U.B.; Dissanayake, D.M.R.; de Silva, D.S.I.; de Silva, H.J.; Premawardhena, A.P. (Sri Lanka Medical Association, 2015)
    INTRODUCTION AND OBJECTIVES: Previous studies suggest that prevalence of hepatitis C (HCV) and hepatitis B (HBV) virus infections is low in Sri Lanka. Patients with severe thalassaemia are at risk of developing blood borne ...

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