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Browsing by Author "Darshana, T."

Browsing by Author "Darshana, T."

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  • Hydroxyurea and blood transfusion therapy for Sickle cell disease in South Asia: inconsistent treatment of a neglected disease 
    Darshana, T.; Rees, D.; Premawardhena, A. (BioMed Central, 2021)
    BACKGROUND: Hydroxyurea and blood transfusion therapies remain the main therapeutic strategies for Sickle cell disease. Preliminary data suggest substantial variation and inconsistencies in practice of these two therapeutic ...
  • Oxidative status in the β-thalassemia syndromes in Sri Lanka; a cross-sectional survey 
    Allen, A.; Perera, S.; Mettananda, S.; Rodrigo, R.; Perera, L.; Darshana, T.; Moggach, F.; Crawford, A.J.; Heirene, L.; Fisher, C.; Olivieri, N.; Rees, D.; Premawardhena, A.; Allen, S. (Elsevier Science-Pergamon Press, 2021)
    ABSTRACT: In the β-thalassemias, oxidative stress, resulting from chronic hemolysis, globin chain imbalance, iron overload and depleted antioxidant defences, likely contributes to cell death, organ damage, anemia, hypoxia ...
  • Oxidative stress and antioxidant deficiency in the β-thalassaemia in Sri Lanka 
    Perera, S.; Allen, A.; Mettananda, S.; Rodrigo, R.; Perera, L.; Darshana, T.; Moggach, F.; Jackson-Crawford, A.; Heirene, L.; Fisher, C.; Olivieri, N.; Rees, D.; Allen, S.; Premawardhena, A. (Sri Lanka Medical Association, 2021)
    Introduction In the β thalassaemias oxidative stress is potentially high and this could be further exacerbated in the absence of robust antioxidant defences, such as nutritional vitamin C and E deficiencies. We undertook ...
  • Possible Application of Sickling Test in Haemoglobinopathy Screening of Sri Lanka. 
    Darshana, T.; Perera, N.; Manamperi, A.; Premawardhena, A. (19th Conference on Postgraduate Research, International Postgraduate Research Conference 2018, Faculty of Graduate Studies,University of Kelaniya, Sri Lanka, 2018)
    The national screening programme for thalassaemia in Sri Lanka is currently using Full blood count (FBC) with red cell indices as the technique to identify haemoglobinopathies. This approach is likely to miss sickle ...
  • Pyrexia of unknown origin (PUO) and the cost of care in a tertiary care institute in Sri Lanka 
    Premathilaka, R.; Darshana, T.; Ekanayake, C.; Chathurangani, K.C.; Mendis, I.; Perinparajah, S.; Shashiprabha, M.; Nishshanka, S.; Tilakaratna, Y.; Premawardhena, A. (BioMed Central, 2023)
    BACKGROUND: Despite advancements in diagnostic technology, pyrexia of unknown origin (PUO) remains a clinical concern. Insufficient information is available regarding the cost of care for the management of PUO in the South ...
  • Sickle cell disease in Sri Lanka: clinical and molecular basis and the unanswered questions about disease severity 
    Darshana, T.; Bandara, D.; Nawarathne, U.; de Silva, U.; Costa, Y.; Pushpakumara, K.; Pathirage, S.; Basnayake, S.; Epa, C.; Dilrukshi, P.; Wijayawardena, M.; Anthony, A. A.; Rodrigo, R.; Manamperi, A.; Smith, F.; Allen, A.; Menzel, S.; Rees, D.; Premawardhena, A. (BioMed Central., 2020)
    BACKGROUND: Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of ...

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