Browsing by Author "de Silva, C."

Now showing 1 - 8 of 8

An Eosinophilic granuloma containing an adult female Wuchereria bancrofti in a patient with tropical pulmonary eosinophilia
(Oxford University Press, 1992) Perera, C.S.; Perera, L.M.; de Silva, C.; Abeyewickreme, W.; Dissanaike, A.S.; Ismail, M.M.
No Abstract Available
A Family with the Noonan Syndrome
(Ceylon College of Physicians, 1984) de Silva, H.J.; de Silva, C.; Wijesiriwardena, B.C.; Chanmugam, D.; Dharmadasa, K.
No Abstract available
Food web: an interactive software for quantifying Wine miller’s trophic networks in fish communities
(Sri Lanka Association for Fisheries and Aquatic Resources, 2004) Weliange, W.S.; Wickramasinghe, R.I.P.; Kumara, K.H.; de Silva, C.; Amarasinghe, U.S.; Vijverberg, J.
Observed properties of aquatic food webs have important management implications as well as important theoretical implications in the subjects of fisheries science and aquatic ecology. The food web approach is useful to understand pathways of energy and material transfer and the structure of the hierarchy of species trophic interactions in aquatic ecosystems. Winemiller (1990) presented a graphical method to investigate spatial and temporal variation in trophic networks in tropical fish communities. A computer programme was developed to produce graphic illustrations of trophic networks in the fish communities and associated food web parameters namely number of nodes, compartmentalization, connectance, average number of prey per node, average number of predators per node and ratio of consumer nodes to total nodes. The input data for this software are relative importance of food items of constituent species in the fish community and the tropic levels of prey items. The graphic illustrations and associated food web parameters mentioned above can be used for spatial and temporal comparison of trophic relationships in fish communities.
Histopathology of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka.
(Hindawi Pub. Co., 2020) Wijesinghe, H.; Gunathilaka, N.; Semege, S.; Pathirana, N.; Manamperi, N.; de Silva, C.; Fernando, D.
ABSTRACT: Cutaneous leishmaniasis (CL) is a neglected tropical disease that is gaining importance in Sri Lanka and internationally. The clinical presentation, pathology, and method of parasite elimination in CL vary according to the species. Leishmania donovani is the causative organism for leishmaniasis in Sri Lanka. This collaborative cross-sectional study describes the clinicopathological features of cutaneous leishmaniasis among personnel of the tri-forces serving in the North and East of the country. The histology of fifty cases of CL confirmed by at least two methods (slit skin smear, lesion aspirate, tissue impression, and histology) was reviewed. The parasitic load was assessed semiquantitatively. The histological features were correlated with the clinical presentation and organism load. The majority (89.8%; n = 44) presented with a single lesion mostly located in the upper limb (69.4%). The lesion types included papule (34.7%), nodule (32.7%), and an ulcer (30.6%). The evolution time of lesions averaged 31.55 weeks. Epidermal changes were observed in 49 of the biopsies and included hyperkeratosis (90.0%; n = 45), acanthosis (44.0%; n = 22), atrophy (34.0%; n = 17), and interface change (66%; n = 33). Dermal changes were seen in all cases and were characterized by a lymphohistioplasmacytic inflammatory infiltrate of variable intensity with ill-formed granuloma in 19 cases (38%) and well-formed epithelioid granulomas in 22 cases (44%). Focal necrosis was present in 20% (n = 10). Leishmania amastigote forms were observed in 88% (n = 44). Transepidermal elimination (P = 0.025), granuloma (P = 0.027) formation, and type of lesion (P = 0.034) were significantly associated with the organism load. Granuloma formation was associated with a reduction in organism load, indicating that the macrophage activation played an important role in the control of the organism.
A large pericardial cystic lymphangioma presenting as acute-onset respiratory distress in a child: a case report
(BioMed Central, London, 2022) Pathiraja, H.; Rasnayake, D.; Muthukumarana, T.; de Silva, C.; Sathkorala, W.; Gunaratne, S.; Rajindrajith, S.; Mettananda, S.
Background: Lymphangiomas are rare benign malformations of the lymphatics that occur due to blockage of the lymphatic system during fetal development. They commonly occur in the neck and axilla, while involvement of the pericardium is rare. We report herein the case of a 16-month-old Sri Lankan child with a large pericardial cystic lymphangioma presenting with sudden-onset shortness of breath. Case presentation: A 16-month-old Sri Lankan boy presented with sudden-onset dyspnea for 1-day duration following a febrile illness that lasted 2 days. On examination, he was afebrile and had subcostal, intercostal, and suprasternal recessions, with a respiratory rate of 50 breaths per minute. He had a loud expiratory grunt. The chest expansion was reduced on the right side, which was dull to percussion. Auscultation revealed a marked reduction of air entry over the right lower and mid zones. Chest X-ray showed a well-demarcated opacity involving the lower and mid zones of the right hemithorax associated with a tracheal shift to the opposite side. Ultrasound scan of the chest revealed fluid-filled right hemithorax suggesting a septate pleural effusion. A contrast-enhanced computed tomography scan of the thorax showed a large multiloculated extrapulmonary cystic lesion involving the right hemithorax with a mediastinal shift towards the left side associated with displacement of the right-side mediastinal structures. He underwent mini-thoracotomy and surgical excision of the cyst. A large cyst originating from the pericardium was observed and excised during surgery. Histological examination revealed a lesion composed of cysts devoid of a lining epithelium but separated by connective tissue, mature adipose tissue, and lymphoid aggregates. The child showed complete recovery postoperatively with full expansion of the ipsilateral lung. Conclusion: We report the case of a patient with cystic lymphangioma who was perfectly well and asymptomatic until 16 months of age. This case report presents the very rare occurrence of a large cystic lymphangioma originating from the pericardium. It highlights the importance of considering rare possibilities and performing prompt imaging in situations of diagnostic uncertainty to arrive at an accurate diagnosis that can be lifesaving.
Sero-negative rheumatoid arthritis in haemoglobin E thalassaemia
(Sri Lanka Medical Association, 1988) de Silva, H.J.; Senaratne, N.L.; Goonetilleke, A.K.; de Silva, C.; Jayawickrama, U.S.; Amarasekera, L.R.
No Abstract Available
A survey study on the effect of occupation and other associated factors towards initiation of amlapitta (gastritis)
(Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, 2014) Hansini, K.G.D.M.; de Silva, C.; Jayathunga, H.D.A.P.; Sirisena, T.P.A.; Thiranagama, R.; Perera, S.
Twin pregnancy chorionicity determination in a tertiary care setting
(Sri Lanka Medical Association, 2013) Dias, T.; Weerasinghe, A.; Amarathunga, P.; de Silva, C.; Thilaganathan, B.
Ultrasound determination of chorionicity is most reliable before 14 weeks and subsequently reduces in accuracy with advancing gestation. The aim of this study was to evaluate the accuracy of chorionicity determination in a birth cohort of twin pregnancies. Antenatal ultrasound determination of chorionicity in twin pregnancy was undertaken at sub optimal period of gestation in over two thirds of twin pregnancies. Even in the first trimester of pregnancy, the accuracy of chorionicity determination was lower than previously reported.