Browsing by Author "Thoradeniya, T."

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Hyperhomocysteinaemia among adolescent girls and young women
(Sri Lanka Medical Association, 2007) Thoradeniya, T.; Atukorala, S.; Wickremasinghe, R.
INTRODUCTION: Moderately elevated plasma total homocysteine (tHcy) is an independent risk factor for adverse pregnancy outcomes and cardiovascular disease in women. OBJECTIVE: To determine the prevalence of hyperhomocysteinaemia and its association with serum folate and vitamin Bi2 concentrations, BMI and waist circumference (indicators of general nutritional status and cardiovascular risk factors) among adolescent girls and young women. DESIGN, SETTING AND METHODS: A sample of 552 adolescent girls aged 15-18.9 years (n=277) and young women aged 19-30 years (n=275) from Colombo municipality were randomly selected for a study conducted on low folate status and anaemia. A sub-sample with tHcy data was selected for the present study (adolescent girls: n=123; young women: n=136). Serum folate and vitamin B,2 were measured. Anthropometric data were obtained and body mass index (BMI) was calculated. RESULTS: Hyperhomocysteinaemia (tHcy>15 umol/L) was observed among 18.9% of subjects (adolescent girls: 19.5% and young women: 18.4%). Though a high prevalence was noted (43.0%) for low folate status (serum folate <3 ng/ml), none of the subjects studied bad serum vitamin B12 <150 pg/ml. Inverse correlations were noted between tHcy and serum folate (r=-0.151, P=0.018) and vitamin B12 ,r=-0.202, P=0.004) concentrations. Interestingly, positive correlations were noted among tHcy and BMI (r=0.168, P=0.007) and waist circumference (r=0.145, P=0.019). CONCLUSIONS: Our results suggest that hyperhomocysteinaemia could be partly attributable to low folate and vitamin B12 status. The associations noted between tHcy and BMI and waist circumference warrants further investigations in relation to food intake and disease outcomes in this population. ACKNOWLEDGEMENT: Financial support: IAEA, Vienna
Influence of baseline inflammatory status on dietary effects of nutrition counseling in women with and without coronary artery disease
(Sri Lanka Medical Association, 2012) Thoradeniya, T.; Senenayake, C.; Wickremasinghe, R.; Mendis, S.; Jayasena, S.; Atukorala, S.
INTRODUCTION: Inflammatory status influences the biochemical response to diet, suggesting an additional mechanism increasing coronary artery disease (CAD) risk. Aims: To determine the effect of baseline inflammatory status on biochemical response to nutrition counseling to reduce CAD risk. METHODS: A 2x2 factorial experiment having an intervention was conducted among 40-60 year old women with (n=101) and without CAD (n=109). Intervention comprised nutrition counseling. Baseline and post-intervention data on diet, serum high sensitivity CRP (hsCRP), soluble ICAM-1 (sICAM-1), ferritin, folate, plasma total homocysteine (tHcy) concentrations and traditional CAD risk factors were assessed. RESULTS: At baseline tHcy, sICAM-1 and hsCRP concentrations were significantly higher (p<0.05) among women with CAD than in women without CAD. Baseline sICAM-1 [OR=3.19 (95"% CI, 1.65-6.17)] and tHcy concentrations [OR=1.33 (95% CI 1.1-1.61)] were independently associated with CAD after adjusting for other risk factors. Nutrition counseling significantly decreased serum total and LDL cholesterol and increased serum folate (p<0.05) in women without CAD, but not in women with CAD. Among women without CAD, nutrition counseling decreased serum total and LDL cholesterol, and increased serum folate (p<0.05) in the "low" hsCRP group (below median of controls) but not in the "high" hsCRP group (above median). CONCLUSIONS: Nutrition counseling was effective in reducing serum total and LDL cholesterol and increasing serum folate in women without CAD having a "low" baseline inflammatory status. The hindering effect of underlying inflammation, on the biochemical response to dietary modification should be considered in dietary interventions in CAD risk reduction.
Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka
(Cambridge University Press, 2006) Thoradeniya, T.; Wickremasinghe, R.; Ramanayake, R.; Atukorala, S.
Folic acid deficiency is implicated in the aetiology of nutritional anaemia and adverse pregnancy outcomes for the fetus. Data on folic acid status among adolescent girls and non-pregnant, non-lactating young women are limited. We assessed folic acid status in a random sample of 552 subjects (277 adolescent girls aged 15-18.9 years and 275 women aged 19-30 years) living in Colombo, Sri Lanka. The association of low folic acid status with anaemia was evaluated. Socio-economic, food intake and anthropometric data were obtained. Hb, serum folic acid, vitamin B12 and ferritin and plasma homocysteine concentrations were measured. Forty-three per cent of subjects studied had low serum folic acid concentrations (<3 ng/ml) and 47 % had low Fe stores (serum ferritin <20 microg/l). Overall prevalence of anaemia was 12.9 %, and 43.9 % of anaemic subjects had both low folicacid status and depleted Fe stores (serum ferritin <12 microg/l). Both low folate status and depleted Fe stores were significantly associated with anaemia (odds ratio = 2.32; 95 % CI 1.34, 4.01 and odds ratio = 5.98; 95 % CI 3.36, 10.63, respectively). Serum folic acid concentration was associated (r = 0.108, P = 0.015) with folate intake as indicated by a computed folate index. Folate index was associated inversely with household size and positively with economic status and education level. In this study population low folic acid status, besides depleted Fe stores, was associated with anaemia. The high prevalence of low folic acid status observed highlights the need for nutrition education to improve intakes of folate, Fe and other micronutrients among adolescent girls and young women.