Browsing by Author "Saparamadu, P.A.M."

Now showing 1 - 5 of 5

A Clinical and cost evaluation between outpatient endometrial biopsy and dilatation and curettage
(Sri Lanka College of Obstetricians and Gynaecologists, 1997) Gunasekera, P.C.; Wijesinghe, P.S.; Saparamadu, P.A.M.
Objective To evaluate the clinical and financial benefits of endometrial aspiration biopsy using a new aspiration device (Probet) over conventional dilatation and curettage. Design Comparison of histology and adequacy of samples obtained by endometrial aspiration and formal curettage. The histopathologist was blinded with regard to the biopsy method. Setting The gynaecology outpatient department of a teaching hospital. Patients 52 consecutive women requiring dilatation and curettage (D and C). Interventions Endometrial aspiration was performed in the out patient department and conventional D and C performed within 3 days. Main outcome measures Degree of discomfort to patients during endometrial aspiration was assessed by a visual analogue scale. Histological adequacy of the endometrial samples obtained was determined. The histological diagnosis of samples obtained by the two methods was passed. Cost of the two methods was determined. Results Eight patients experienced moderate to severe discomfort during endometrial aspiration. These were done for investigation of subfertility (2) and postmenopausal bleeding (6). Scanty or no endometrial aspirate was obtained in 9 women, 6 of whom had postmenopausal bleeding. No curettings were obtained in 5 of the women with postmenopausal bleeding. Active bleeding was present at the time of the procedure in 5 patients which was reported as blood clot and menstrual endometrium. In only 2 of the paired endometrial samples did the histological diagnosis differ from the specimen obtained by endometrial aspiration. Histological concordance was noted in 30 pairs. Conclusions Outpatient endometrial biopsy is acceptable to the majority of patients. Nulliparous and postmenopausal woman feel discomfort. Endometrial biopsy in the presence of active bleeding is of little value. There is good histological concordance between samples from endometrial aspiration is as ten times cheaper than conventional curettage
Efficacy of Liv 52 in alcoholic liver disease
(Sri Lanka Medical Association, 2001) de Silva, H.A.; Thabrew, M.I.; Saparamadu, P.A.M.; Pathmeswaran, A.; Fonseka, M.M.D.; de Silva, H.J.
OBJECTIVE: To assess the efficacy of Liv 52 in patients with alcoholic liver disease. METHOD: A randomized, double-blind, placebo-controlled trial was conducted at Teaching Hospital. Ragama. 80 patients with alcoholic liver disease who fulfilled inclusion criteria were randomly assigned Liv 52 (cases; n=40) or placebo (controls) three capsules twice daily for six months. All subjects underwent clinical examination, and laboratory investigations for routine blood chemistry, serum cholesterol and liver function before commencement of therapy (baseline). Thereafter, clinical assessments were done monthly, while laboratory investigations were done after 1 month and 6 months of therapy. RESULTS: There was no significant difference in the age composition, alcohol intake and baseline liver function between the two groups. The two sample t-test was used to analyze data obtained after 2,3.4,5 and 6 months of therapy against baseline values. There was no significant difference in clinical outcome and liver chemistry between the two groups at any time point. No adverse effect attributable to the drug was reported. CONCLUSION: Liv 52 does not seem to be useful in the management of patients with alcohol induced liver disease.
Gender issues among medical students in sri lanka: a preliminary Study
(Sri Lanka Medical Association, 2000) de Silva, N.R.; Thabrew, I.; Saparamadu, P.A.M.; Jayawardena, D.K.R.C.
OBJECTIVE: Find out if gender issues affect the progress of medical students ill Sri Lanka, METHOD: Students of the Medical Faculty, Kelahrya University, were given a questionnaire that explored gender issues in relation to academic and extracurricular activities in the Faculty. Results of examinations conducted by the Faculty in 1997 and 1998, and data published by the University Grants Commission on final examinations conducted by four other medical faculties in 1996 and 1997 were also analysed for sex-related differences using the X test for dichotomous variables. RESULTS: The questionnaire was completed by 651/855 (76.1%) of registered students, including 341 females. Overall, most (43.6-73.0%) felt that their training was not affected by gender, but 14-42% (both male and female) answered positively; the percentage increased significantly with seniority (X2for linear trend-16.483, p=0.005). Females were significantly less likely to participate in extracurricular activities (220/341 vs. 239/310, X2=12.36, p<0.001). The proportion of females who obtained classes were higher than that of males in 12/15 examinations analysed, with statistically significant differences in four (two in Kelaniya and one each in Peradeniya and Ruhuna). Higher proportions of males were referred / failed in all eight examinations analysed; the differences were statistically significant in rwo. CONCLUSIONS: A significant minority of medical students of both sexes in the Kelaniya University feels that their gender is a disadvantage to them during training. Female students appear to do marginally better than males in undergraduate examinations.
Geneder differences in undergraduate medical examination results in Sri Lanka
(Sri Lanka Medical Association, 2000) de Silva, N.R.; Thabrew, M.I.; Saparamadu, P.A.M.; Jayawardena, D.R.K.C.; Arachchige, A.A.; Weerawardhane, M.; Gunawardene, Y.I.N.S.
OBJECTIVE: To identify possible gender related differences in performance at undergraduate medical examinations in Sri Lanka. STUDY DESIGN AND METHODS: Results of examinations conducted by the faculty of medicine, University of Kelaniya in 1997 and 1998, and data published by the University Grants Commission (UGC) on final examinations conducted by 4 other Sri Lankan medical faculties (in the Universities of Colombo, Peradeniya, Ruhuna and Jaffna) in 1996 and 1997, were analysed for sex related differences.RESULTS: The proportion of women in each batch of students who sat for 8 examinations conducted at the faculty of medicine, University of Kelaniya in 1997 and 1998, ranged from 40.7 to 48.4% (average 44.3%). Among students sitting for the final MBBS examinations in other medical faculties in 1996 and 1997, the proportion of women ranged from 37.3% in Peradeniya to 53.7% in Jaffna. The proportions of women who obtained "classes" were higher than that of men in 12/15 examinations, with statistically significant differences in four. Higher proportions of men were referred or failed in all 8 examinations analysed; the differences were statistically significant in two. CONCLUSIONS: Women appear to do marginally better than men in undergraduate medical examinations in Sri Lanka.
Liv. 52 in alcoholic liver disease: a prospective controlled trial
(Elsevier, 2003) de Silva, H.A.; Saparamadu, P.A.M.; Thabrew, M.I.; Pathmeswaran, A.; Fonseka, M.M.D.; de Silva, H.J.
Liv.52, a hepatoprotective agent of herbal origin, is used empirically for the treatment of alcoholic liver disease in Sri Lanka. We conducted acontrolled trial to assess the efficacy of Liv.52 in patients with alcoholic liver disease. Patients with evidence of alcoholic liver disease attending outpatient clinics were included in a prospective, double blind, randomized, placebo controlled trial. During the trial period, 80 patients who fulfilled inclusion criteria were randomly assigned Liv.52 (cases; n = 40) or placebo (controls) the recommended dose of three capsules twice daily for 6 months. All patients underwent clinical examination (for which a clinical score was computed), and laboratory investigations for routine blood chemistry and liver function before commencement of therapy (baseline). Thereafter, clinical assessments were done monthly for 6 months, while laboratory investigations were done after 1 and 6 months of therapy. There was no significant difference in the age composition, alcohol intake and baseline liver function between the two groups. The two-sample t-test was used to analyze data obtained after 1 and 6 months of therapy against baseline values. There was no significant difference in clinical outcome and liver chemistry between the two groups at any time point. There were no reports of adverse effects attributable to the drug. Our results suggest that Liv.52 may not be useful in the management of patients with alcohol induced liver disease.