Browsing by Author "Peiris, K.P.P."

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Analgesic Activity of Water Extract of Spilanthes acmella Flowers on Rats
(Journal of Trop medical plants, 2001) Peiris, K.P.P.; Silva, G.K.J.; Ratnasooriya, W.D.
The objective of this study was to evaluate the analgesic potential of fresh flowers of Spilanthes acmella Murr. (family: Compositae) used by some Sri Lankan traditional medical practitioners to suppress toothache. Different doses of water extract of fresh flowers (111,335 and 671 mg kg-1 ) were orally administered to male rats and their analgesic potential was determined at different post treatment periods by using hot plate and tail flick tests. Sedative potential of the extract was evaluated by using rat hole board technique. The extract was well tolerated. A dose-dependent analgesic activity with a EC50 =313 mg kg-1was evident when evaluated in hot plate but not in tail flick test. This analgesic activity had a rapid onset and short duration of action and was not blocked by naloxone, an opioid receptor antagonist. The mid dose of the also induced significant sedation, It is concluded that the analgesic activity is mediated supra-spinally accompanied with sedation.
Anti-inflammatory and Analgesic activities of Dashana Samskara Churna and its' paste form
(Indian Journal of Natural Products and Resources, 2011) Peiris, K.P.P.; Ashok, B.K.; Manjusha, R.; Ravishankar, B.
Anti-inflammatory and analgesic activities of Dashana Samskara Chuma and its paste form were examined in different animal models. Anti-inflammatory activity was evaluated in acute, sub-acute and chronic inflammatory models and compared with Phenylbutazone, Diclofenac sodium and Dexomethasone standards, respectively. Analgesic activity was evaluated in formalin induced paw licking (chemically induced pain) and tail flick method (thermally induced pain) where Indomethacin and Pentazocine were used as standard drugs, respectively. Test formulation in the form of paste inhibited the carrageenan induced paw oedema (P<0.05), formalin induced paw licking (P
Antibacterial activity of two different Prathisaranas against periodontitis.
(Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Abegunasekara, N.S.; Peiris, K.P.P.; Sudesh, A.D.H.
'Kushtaadi Choorna and Shwethamanjana Choorna' are used in the treatment ofDanthamulagatha Roga such as Sheethada, Danthaweshta and Upakusha. These formulations are used specially as a local treatment. Staphylococcus aureus and Methicillin resistant Staphylococcus aureus (MRSA) are main causative organisms of periodontal diseases. The present study was carried out to determine the antibacterial activity of Kushtaadi choorna andShwethamanjana choorna using agar well diffusion method in comparison with standard antibiotic Amoxicillin against the Staphylococcus aureus (ATCC 25923) and Methicillin resistant Staphylococcus aureus (MRSA). The samples of Prathisarana were prepared in ne powder form, Amoxicillin as positive control and triplicates were made for each test. Observation was recorded by measuring the diameter of the inhibitory zones surrounding the wells. According to the results, inhibitory effect of both Prathisarana samples were signicantfor Staphylococcus aureus and Methicillin resistant Staphylococcus aureus (MRSA).
An Ayurvedic Appraoch in the management of Ashmari (Urolithiasis)
(International Journal of Current Innovations in Advanced Research, 2019) Samaranayake, G.V.P.; Peiris, K.P.P.; Pushpakumara, A.A.J.
In ancient centuries urolithiasis was often a disease, with a catastrophic outcome all too often leading to the patient's death. Even today, urolithiasis is the one of the most common affliction of the urinary tract. Detailed medical literature on urolithiasis is available from ancient India. As per classics, Ashmari is included in Ashtamahagada due to its fatal nature. Description of Ashmari is found in almost all Samhita Of Ayurveda as etiopathogenesis, classification, symptomatology, complications and management in a most scientific manner- Modem science also emphasizes on involvement of various factors like heredity, age, sex, metabolic disorders, hydration status, mineral content of water, nutritional deficiency, etc. For urinary stone formation. Urolithiasis typically occurs in middle age which is the most productive years of life. It causes pain, loss of working time, medical expenses, needs for hospitalization as well as it is infrequent cause of renal failure and death. Different management of urolithiasis has been developed in modern system but inspite of all these techniques, surgery remain treatment of choice. Even after surgery patients have to take medicines to check its further recurrence. In this way the need of medicinal treatment is always required.
An Ayurvedic Appraoch in the management of Ashmari (Urolithiasis)
(International Journal of Current Innovations in Advanced Research, 2019) Samaranayake, G.V.P.; Peiris, K.P.P.; Pushpakumara, A.A.J.
In ancient centuries urolithiasis was often a disease, with a catastrophic outcome all too often leading to the patient's death. Even today, urolithiasis is the one of the most common affliction of the urinary tract. Detailed medical literature on urolithiasis is available from ancient India. As per classics, Ashmari is included in Ashtamahagada due to its fatal nature. Description of Ashmari is found in almost all Samhita Of Ayurveda as etiopathogenesis, classification, symptomatology, complications and management in a most scientific manner- Modem science also emphasizes on involvement of various factors like heredity, age, sex, metabolic disorders, hydration status, mineral content of water, nutritional deficiency, etc. For urinary stone formation. Urolithiasis typically occurs in middle age which is the most productive years of life. It causes pain, loss of working time, medical expenses, needs for hospitalization as well as it is infrequent cause of renal failure and death. Different management of urolithiasis has been developed in modern system but inspite of all these techniques, surgery remain treatment of choice. Even after surgery patients have to take medicines to check its further recurrence. In this way the need of medicinal treatment is always required.
An ayurvedic approach in the management of Menier’s Disease: A case study
(4th International Conference on Ayurveda, Unani, Siddha and Traditional medicine(4th ICAUST 2016), 2016) Abegunasekara, N.S.; Peiris, K.P.P.
Hearing impairment or deafiress is most commonly seen in almost all the age groups because of the noise pollution, drug abuses, bad dietary habits, stressful life where the Neuropsychiatric problems are seen, and Meniere's disease is one of them. Meniere's disease is characterized by episodic vertigo, fluctuating senso-neural hearing loss, tinnitus and aural fullness. This illness occurs at irregular and unpredictable intervals. Tinnitus and deafness may be absent during the initial phase of attack of vertigo but invariably these syrnptoms appear as the disease progresses. This study was aimed to observe the efficacy of Ayurveda treatments in the management of Meniere's disease. It was conducted at Shalakya clinic of Gampaha Wickramarachchi Ayurveda teaching hospital. This study describes a case of clinically diagnosed 41 years old male patient with sign and symptoms of Meniere's disease. He was administrated with Ayurveda Medicine for three (03) months without discontinuation. Treatment protocol was consisted with local and systemic therapies. After 14 days of therapy there was a marked improvement of vertigo. At the end of follow-up period complete remission of symptoms were observed. So, It is concluded that the treatment protocol which is used to treat the patient was effective in the management of Meniere's disease.
Ayurvedic management of Branch Retinal Vein Occlusion: a case study.
(Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Abegunasekara, N.S.; Peiris, K.P.P.
Branch Retinal Vein Occlusion (BRVO) is one of the major causes of sudden painless loss of vision after diabetic retinopathy. Two third of patients with ischemic BRVO are prone to blindness.There has been no treatment identied so far to reverse open the blocked vessels to maintain perfusion and the available treatment modality (laser photocoagulation) is not effective in the absence of macular perfusion. The purpose of this study was to evaluate the efcacy of selected Ayurveda modalities in the management of BRVO and to study the pathogenesis of BRVO. A 68 year-old male patient with unilateral BRVO reported to the Shalakya clinic, having a visual acuity 3/60 in right eye and 6/24 in left eye with distorted vision and visual eld defect. His near vision was CF in right eye and N8 in left eye. The patient did not have any other complications such as diabetic, hypertension or any other systemic disease. He was administrated with selected Ayurveda modalities for three (03) months continuously. Treatment protocol consisted of local and systemic therapies. After 14 days of therapy, there was marked improvement of visual acuity. At the end of follow-up period complete remission of symptoms was observed. Thus it is concluded that the treatment protocol which was used to treat the patient was effective in the management of BRVO.
A clinical study on the efficacy of Trataka Yoga in the management of Thimira
(Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, 2014) Pamodani, M.P.N.; Peiris, K.P.P.
A clinical study on the efficacy of Warnakalepa in the Management of hyperpigmentation
(Institute of Indigenous Medicine, University of Colombo, Rajagiriya, Sri Lanka, 2014) Pramodani M.P.N.; Peiris, K.P.P.
Comparative anti -plaque effect of herbal dental formula
(International Journal of Current Advanced Research, 2020) Peiris, K.P.P.; Rupasinghe, R.A.A.N.
Ayurveda and Sri Lankan traditional medical system devotes a significant importance to oral health problems on its preventive aspect rather than curative. This herbal formulation is specified as a dentifrice in Thalpathe Piliyam. But it was not scientifically evaluated. Therefore, this study was carried out to evaluate the effectiveness of reducing plaque accumulation on teeth, maintenance of oral hygiene and compare the efficacy of powder with the novel toothpaste. Forty patients were selected with written consent from Dental OPD. They were randomly divided in to two groups; group A and B (20 patients in each) irrespective of their sex, religion, habitat etc. Group A was advised to brush twice a day for 01 month by using the toothpaste and Group B from same formula as in powder form. Oral Hygiene Index (OHI -S), Calculus Index (CI - S), Debris Index (DI —S) and Plaque Index (P Il) were used as objective criteria. According to the statistical analysis, it can be concluded that clinical effectiveness of toothpaste is more significant than tooth powder. Therefore, long term studies should be carried out to confirm the result.
Comparative anti -plaque effect of herbal dental formula
(International Journal of Current Advanced Research, 2020) Peiris, K.P.P.; Rupasinghe, R.A.A.N.
Ayurveda and Sri Lankan traditional medical system devotes a significant importance to oral health problems on its preventive aspect rather than curative. This herbal formulation is specified as a dentifrice in Thalpathe Piliyam. But it was not scientifically evaluated. Therefore, this study was carried out to evaluate the effectiveness of reducing plaque accumulation on teeth, maintenance of oral hygiene and compare the efficacy of powder with the novel toothpaste. Forty patients were selected with written consent from Dental OPD. They were randomly divided in to two groups; group A and B (20 patients in each) irrespective of their sex, religion, habitat etc. Group A was advised to brush twice a day for 01 month by using the toothpaste and Group B from same formula as in powder form. Oral Hygiene Index (OHI -S), Calculus Index (CI - S), Debris Index (DI —S) and Plaque Index (P Il) were used as objective criteria. According to the statistical analysis, it can be concluded that clinical effectiveness of toothpaste is more significant than tooth powder. Therefore, long term studies should be carried out to confirm the result.
A comparative study of Dashana Samskara Choorna Pratisarana and Dashana Samskara paste application in the management of Sheetada (Gingivitis)
(AYU Journal, 2013) Peiris, K.P.P.; Rajagopala, M.; Patel, N.
Sheetada is the early stage of periodontal diseases. This occurs due to negligence of oral hygiene, changing life-style, habits, and addlctions. It is Kapha Rakto Prodhana Vyodhi In modern dentistry papillary or marginal gingivitis can be correlated with Sheetada, on the basis of similarities in symptoms, involvement of anatomical structure, etiology and prognosis. The epidemiological studies conducted by American Academy of Periodontology shows that gingivitis of varying severities is nearly universal. It is estimated that over 80% of the world's population suffers from gingivitis. In this clinical study, 106 patients were registered among them 103 completed the treatment and were randomly divided by lottery method into two groups. In Group-A Dashono Samskara paste local application on gums and in Group-B, Dashana Samskaro Choorno Pratisarana on gums was given.After enrollment of the patients in the study cardinal symptoms of Sheetada (gingivitis) such as, Raktasrava, Krishnata, Prakledata, Mriduta, Mukhodaurgandhya, and also the objective criteria such as oral hygiene index, Gingival Index (GIS), and Gingival Bleeding Index (GBI-S) were studied before and after the treatment. While considering comparative effect on subjective parameters such as Raktasrava, Dantamomsa Shiryomonato, Shotho and Chalata statistically significant results were obtained in Group-A than Group-B. In objective parameters such as, GI-S and GBI-S also showed statistically significant results in Group-A. Observations in follow-up study confirmed that the recurrence rate in the Group-Awas significantly lesser than the Group-B.
A Comparative Study of Shiro Abyanga & Shiro lepa in the Management of Khalithya
(2015) Peiris, K.P.P.; Sadungama, M.K.N.G.; Pramodine, M.P.N.
Comparative study on different treatment modules in the management of Fistula – In - Ano (Bhagandara)
(International Journal of Current Advanced Research, 2020) Samaranayake, G.V.P.; Pushpakumara, A.A.J.; Peiris, K.P.P.
Bhagandara is a common disease occurring in the ano-rectal region. Acharya Susruta, the father of surgery has included this disease as one among the Ashtamahagada. It can be correlated with Fistula-in-ano as described in western medical science. Fistula-in-ano is a track lined by granulation tissue which opens deeply in the anal canal or rectum and superficially on the skin around the anus. The incidence of a Fistula-in-ano developing from an anal abscess ranges from 26-38%. The prevalence in men is 12.3 cases per 100 ,000 populations and in women are 5.6 cases per 100,000 populations. The male to female ratio is 1.8: l. The mean age of patients is 38.3 years. This randomized prospective cohort clinical study was done to compare and evaluate the effect of new herbal formulation consisting of Vitex nigundo(root), Crativa adansoni (bark), Ricinus communis (bark), Plumbago indica(root) in managing fistula-in-ano conditions of patients in comparison to the effect of tripala decoction and kshara sutra. The patients were selected according to the selection criteria and randomly assign in to 2 groups (Group A, Group B) consisting of 20 patients for each. The patients of Group A was be treated with, Tripala decoction, kshara sutra and prescribed dietary management. The patients of group B were treated with, new herbal formulation, kshara sutra and prescribed dietary management during the period of 8 weeks. In the group A and group B mean changes or decrement of pain, burning sensation, itching and discharge, P values = 0.00 95% confidence level P < 0.05 both groups are same P=O.()()O. Therefore, no difference between both groups and it shows statistically significant. In the group A mean decrement of length of the fistulous track P value p = 0.005 at confidence level P < 0.05. It shows a significant decrement of the length of fistulous track statistically in 95% confidence level. In the group B mean decrement of length of fistulous track P value p = 0.000 at 95% confidence level P < 0.05. It shows a significant decrement of the length of fistulous track statistically in 95% confidence level. But mean decrement of length of fistulous track of the group B greater than that of group A, which means group B more statistically significant. Finally, based on the observed results and the pharmacodynamic properties of both treatment protocols, it may be concluded that new herbal formulation + kshara sutra + dietary management treatment module is more effective than Tripala decoction + kshara sutra + dietary management in the management of fistula-in-ano.
A Comparative Study on the Anti-microbial efficacy of Two Ayurveda Powders (Prathisarana) Used in Periodontal Disease
(International Journal of Dental Science and Innovative Research (IJDSIR), 2019) Peiris, K.P.P.; Samaranayake, G.V.P.; Wijebandara, D.M.K.K
Kushtadi (KU) and Karanjadi (KR) are prominently used Ayurvedic powders (Prathisarana) in the management of periodontal diseases. This study was carried out for the determination of antimicrobial efficacy of these two drugs using standard Antimicrobial Sensitivity Test against Candida albicans and a fungal culture isolated from a patient. The Antimicrobial Sensitivity Test was performed according to the Well diffusion method having 6 mm diameter wells on Sabouraud Dextrose Agar (SDA). Each well was loaded with test drugs mixed in 20 gl of sterile distilled water and fluconazole 2.5 mg/ml as the positive control. According to the results, KR showed an average Inhibition Zone Diameter (iZD) of 20 mm for the isolated culture while KU did not show any inhibition. The results were similar for Candida albicans and KR showing IZD 18 mm, KU IZD 0 mm while positive control giving an Inhibition of 25 mm. Therefore, it can be concluded that Candida albicans and the isolated culture were sensitive Only for KR making it the only effective drug out of the two drugs tested in this study.
A comparative study on the anti-microbial efficacy of two Ayurveda powders (Prathisarana) used in periodontal diseases
(Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Wijebandara, D.M.K.K.; Peiris, K.P.P.; Karunarathna, E.D.C.; Sudesh, A.D.H.
Kushtadi (KU) and Karanjadi (KR) are prominently used Ayurvedic powders (Prathisarana) in the management of periodontal diseases. This study was carried out for the determination of antimicrobial efcacy of these two drugs using standard Antimicrobial Sensitivity Test against Candida albicans and a fungal culture isolated from a patient. The Antimicrobial Sensitivity Test was performed according to the Well diffusion method having 6mm diameter wells on Sabouraud Dextrose Agar (SDA). Each well was loaded with test drugs mixed in 20μl of sterile distilled water and uconazole 2.5mg / ml as the positive control. According to the results, KR showed an average Inhibition Zone Diameter (IZD) of 20mm for the isolated culture while KU did not show any inhibition. The results were similar for Candida albicans, KR showing IZD 18 mm, KU IZD 0 mm while positive control showed an inhibition of 25 mm. Therefore, it can be concluded that both Candida albicans and the isolated culture were sensitive only for KR making it the only effective drug out of the two drugs tested in this study.
A comparative study on the efficacy of Patoladi Lepa Pratisarana and Mustadi Taila Gandusha in the management of Krimidanta (Dental Caries)
(Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Kumaradharmasena, L.S.P.; Peiris, K.P.P.; Kamal, S.V.
According recent statistics, more than 50% of Sri Lankan and 36% of world population are suffering from Krimidanta (Dental Caries). Dental Caries is a multi-factorial process that affects on hard dental tissues such as enamel, dentin etc. Once it occurs, its manifestations persist throughout life even though the lesion is treated. Therefore, an effective therapy is required in the treatment of Krimidanta at its early stage, which is simple, safe and effective. In this study, Patoladi Lepa and Mustadi Taila were used as research drugs which have been prescribed in Cakkradatta. A total sample of 60 patients were selected at Ayurvedic Teaching Hospital, Borella and Gampaha Wickramarachchi Ayurveda Hospital, Yakkala. They were divided equally into two groups by using simple random sampling method. Group A was treated with 2g of Patoladi Lepa Pratisarana twice a day and Group B was prescribed 20ml of Mustadi Taila Gandusha twice a day for 4 weeks. Both groups showed signicant results in the improvement of Dantashula, Shopha, Mukha Daurgandhyata, Danta Harsha, Animitta Ruja, Salivary pH and OHI-S. Howwever, chalata was improved in Group B patients only. Improvement in Krishnata was not observed in both the therapies. In the view of all the subjective and objective criteria and recurrences of the clinical features, Mustadi Taila Gandusha has shown better effectiveness than Patoladi Lepa Pratisarana. Therefore, these formulations can be used together at the early stage of Krimidanta as a prophylactic measure.
Determination of antimicrobial efficacv of four Ayurveda Local Applications (Pratisarana Yoga) in the management of Periodontal Disease
(International Journal of Applied Science and Research, Volume 2, Issue 3, 2019) Peiris, K.P.P.; Wanigasekara, D.N.; Sudesh, A.D.H.; Katunatathne, E.D.C.
This study evaluates the antimicrobial activity of four Ayurvedic formulations namely Kushtadi Ehurna, Swethamaniana Churna, Karanladi Churna and Dasana Sanskara Churna that are used to treat periodontal diseases as local applications. The objectives are to find out the presence or absence of in-vitro antimicrobial efficacy of these four drugs and to evaluate the antimicrobial efficacy of them using agar well diffusion method. The organisms used for the study are Staphylococcus aureus (ATCC 29213), Metlucillin resistant Staphylococcus aureus (ATCC 25923) and clinically isolated Candida albicans. The results of the in-vitro antimicrobial efficacy study reveals that Swethamanjana Chuma possesses antimicrobial action against all three tested microorganisms. Kushtadi Churna is cffcctivc against S. aureus (ATCC 29213) and MRSA (ATCC 25923) and it is unable ro affect rhe growth of C. albicans. Karaniadi Churna and Dasana Sanskara Chuma are effecnve against S. aureus (ATCC 29213) and C. albicans and not effective against MRSA(ATCC 25923). Fluconazole and Amoxicillin are used as positive controls for the yeast and two bacteria respectively.
Diuretic activity of Spilanthes acmella flowers in rats
(2004) Ratnasooriya, W.D.; Peiris, K.P.P.; Samaratunga, U.; Jayakody, J.R.A.C.
ln the Sri Lankan traditional medicine. Spilanthes acmella Murr. (Family: Compositae) flowers are claimed to possess powerful diuretic activity. However, as yet, the diuretic potential of these flowers is not investigated by scientifically controlled studies. The aim of rhis study was to evaluate the diuretic potential of Spilanthes acmella flowers in rats using a cold-water extract (CWE). Difl-erent concentrations of CWE (-500. 1 000, I 500 mgArg) or vehiclc or furoscmide ( 13 mg/kg) were orally administered (// : 6 per each treatrrent -uroLrp) to hydrated rats and their urine output was monitored at several intervals of time (l*-5h). The highest dose of CWE significantly (P < 0.0-5) and markedly increased the urine output. The onset of this diurctic actjon was extremeiy prompt (within I h) and lasted thror-rghoLlt the stuciied pedocl (up to -5 h). The peak efTect was evident between 1 and 2 h. Further, the intensity of diLrresis induced by the CWE in the first hi..ur rvas almost simiiar to that of furosemide. Spilanthes acmella CWE also caused marked increase in urinary Na+ and K+ levels and a reduction in the osmolarity of urine suggesting that it is mainly acting as a loop diuretic. lt may also inhibit ADH release and/or action. It is concluded that the Spilanthes acmella CWE has strong diuretic action as is claimed.
Effect of an indigenous drug formulation (Churna) on clotting of mammalian blood
(Gampaha Wickramarachchi Ayurveda Institute, 2006) Peiris, K.P.P.; Samaratunga, U.; Jayakody, J.A.R.C.; Ratnasooriya, W.D.