Browsing by Author "Nusliha, A."

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Congenital hypertrophy of retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP); a polyposis registry experience
(BioMed Central, 2014) Nusliha, A.; Dalpatadu, U.; Amarasinghe, B.; Chandrasinghe, P.C.; Deen, K.I.
BACKGROUND: Familial Adenomatous Polyposis (FAP) is an autosomal dominant condition giving rise to multiple adenomatous polyps in the colon which invariably become malignant by the fourth decade. Congenital hypertrophy of retinal pigment epithelium (CHRPE) is one of its extra intestinal manifestations early in childhood seen, present in 90% of FAP population and is easy to detect. FINDINGS: Patients diagnosed with FAP and at risk first degree family members were screened for CHRPE using a slit lamp and indirect ophthalmoscopy. The retina of 17 diagnosed FAP patients and 13 individuals at risk were examined. The site and size of CHRPE lesions were documented. Thirteen (76%) of 17 FAP patients (male-10, female - 7, median age - 30 years; range 15-55 years) had CHRPE lesions; seven (54%) had bilateral CHRPE lesions and six (46%) had unilateral lesions. A single lesion was detected in 6 (46%) while 7 (54%) patients had multiple lesions. Of 13 at risk individuals (7- male, female-6 ; median age 34; range 16-52 years), one was positive for CHRPE and 12 were free of retinal lesions. The sensitivity of the presence of a CHRPE lesion in association with colonic polyps in FAP was 76%, specificity 92%, positive predictive value 93%, and negative predictive value 75%. CONCLUSIONS: This study found a high sensitivity and specificity for a CHRPE lesion to be associated with colonic polyps of FAP and hence a useful screening method in a burdened health-care system. The method is minimally invasive and simple and would be of particular value in screening children at risk for FAP
Extent of patient delay and its clinical implications among breast cancer patients of the professorial surgical unit, NCTH, Ragama
(Research Symposium 2010 - Faculty of Graduate Studies, University of Kelaniya, 2010) Dharmasiri, K.B.V.S.V.T.; Perera, H.A.S.S.; Nusliha, A.; Ariyaratne, M.H.J.
Introduction Delay in diagnosis of breast cancer results in poor outcome. Objective The aim of the study was to assess the extent of patient delay and its association with presenting complains, breast self-examination, stage of breast cancer at presentation and time of presentation. Method Retrospectively analyzed the data from the breast cancer registry (March 1999- December 2009) maintained at professorial surgical unit, NCTH, Ragama. All patients of the registry included in the study. Patients who detected by screening test (except breast self-examination) were excluded. Patient delay was defined as time from onset of first symptoms to first consultation of a doctor. Patient delay of >3 month considered as late presentation and <3 month early presentation. Results Of the study population (n=134, median age 52, range 30-88years) majority was late presenters (88, 65.6%). The median patient delay was 170days (range 1- 72days). A palpable lump in the breast was the commonest presenting complain among both early (28, 60.8%) and late (48, 54.5%) presenters. Of the early presenters 11 (23.9%) and of the late presenters 12(13.6%) performed breast self-examination. Twenty-seven (47.8%) of the early presenters 32(36.3%) of the delayed presenters had early stage breast cancer at presentation. There have been 36 (72%) late presenters among first 5patients and 29(58%) late presenters among last 5patients of the breast cancer registry. Conclusion Most of the patients are late presenters but duration of patient delay has improved with time. Health conscious patients who performed breast self-examination seem to present early for medical advice. Early presentation may improve the patient outcome because majority has early stage breast cancer.
Familial adenomatous polyposis (FAP) and papillary thyroid cancer: A rare form of familial cancer syndrome
(College of Surgeons of Sri Lanka, 2012) Nusliha, A.; Fernando, F.R.; Deen, K.I.; Dalpatadu, K.U.A.; Prasanna, W.L.A.D.A.
No Abstract Available