Browsing by Author "Jayatunge, D.N.U."

Now showing 1 - 3 of 3

Clinically benign breast lumps - how often are they malignant?
(12th Annual Research Symposium, University of Kelaniya, 2011) Jayatunge, D.N.U.; Pinto, M.D.P.; Ariyaratne, M.H.J.
Breast cancer in women is a major public health problem throughout the world. One in ten of all new cancers diagnosed worldwide each year is a cancer of the female breast. Diagnosis of breast cancer is done by triple assessment considering clinical/cytological and radiological behaviour of a breast lump. First encounter of patients with a breast lump is commonly with a primary care physician in our clinical practice. The objective of this study is to assess the case load of carcinoma of the breast presenting as clinically benign breast disease. Retrospective analysis of data from the breast cancer registry (1999-2011) of the Professorial Surgical Unit, NCTH was done. Examination findings of all the patients in the registry were analyzed. Patients who presented a single, well defined, firm, freely mobile breast lump with no nipple discharge or palpable axillary lymph nodes were considered to be clinically benign. Study population consisted of 145 patients (n=145) with a mean age of 53.23 years and a range between 30-84 years. 12 (8.27%) patients with a mean age of 48.33 years presented with above mentioned criteria. With completion of triple assessment, all of them were diagnosed to have carcinoma of the breast. In our setting about 1 in 10 patients with a carcinoma of the breast may present as having a benign breast lump clinically. Thus it is important to conduct cytological and radiological assessment in all patients presenting with a breast lump especially after the age of 40.
Comparison of Mucin Patterns in Colonic Pathologies by Histochemistry.
(College of Pathologists of Sri Lanka, 2019) Ratnayake, R.M.U.S.; Epitakaduwa, C.; Jayatunge, D.N.U.; Ediriweera, D.; Hewavisenthi, S.J.D.S.
INTRODUCTION: High Iron Diamine Alcian blue (HID-AB) is a well-established technique for demonstrating colonic acid mucins namely sulphomucins (brown- black) and sialomucins (blue). In certain colonic pathologies expression of sulphomucin, the predominant mucin in normal colonic epithelium is altered. OBJECTIVE: To compare the changes in the pattern of mucin staining in, adenocarcinoma (AC), normal colonic epithelium, solitary rectal ulcer (SRU), transitional zone mucosa (TZ) (i.e.: normal non dysplastic mucosa adjacent to adenocarcinoma) and in ulcerative colitis (UC). METHOD: AC-21, normal colonic epithelium-30, SRU-23, TZ-20, UC-29 biopsies were stained with the HID-AB stain. Two investigators assessed the percentages of mucin staining by counting the number of cells staining for sulphomucin and sialomucin in an area of colonic epithelium measuring 1mm in length. The differences in these 5 categories were assessed for statistical significance using the one-way ANOVA test and a Post Hoc Comparison of the mean values was carried out to establish which groups were different. RESULTS: ACs showed no sulphomucin or sialomucin staining while normal colonic epithelium showed nearly 100% sulphomucin staining. The percentage mean value for sulphomucin staining was AC-12.47%, normal colonic epithelium - 96.7%, SRU-35.7%, TZ-48.98%, and UC –75.43%. Hence the differences between these categories reached a level of statistical significance except between TZ and SRU. CONCLUSION: The patterns of mucin staining observed with HID/AB staining included relatively similar changes in mucin staining in the TZ and SRU, the loss acid mucin staining in AC and the relatively mild degree of sulphomucin loss in UC. Though there are significant differences in mucin staining between some of these colonic pathologies practical problems were encountered in using HID/AB as a diagnostic tool.
The Value of sentinel node biopsy in breast cancer
(College of Surgeons of Sri Lanka, 2012) Ariyaratne, M.H.J.; Jayatunge, D.N.U.
No Abstract Available