Browsing by Author "Herath, P."

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    The Impact of Organization Culture on “ITIL Project Implementations” of ITSM in Sri Lanka
    (Faculty of Graduate Studies, University of Kelaniya, Sri Lanka, 2016) Herath, P.; Prabhashini, J.; Katepearachchi, G.K.
    Many IT organizations adopt industry framework to guide, standardize, fine-tune, streamline IT service delivery process. Information Technology Infrastructure Library (ITIL) is one of the industry frameworks in IT Service Management (ITSM). In fact, industry experts often suggest the ITSM organizations to start with configuration, implementation, and deployment of ITSM projects, whilst people factor was neglected! Integrated system implementations are change initiatives of organizations (Hong, 2002). Changes to seek better process improvements and will call optimize service delivery to achieve agreed service level. Making changes to current business processes is hard due to this people factor (Hong, 2002). Dharmasiri (2015) found organization or corporate culture is the pattern of values, norms, beliefs, attitude and assumptions that may show people factor of project implementation. Today, cultural change in every organization is imminent. Being in the IT industry many of us associated experience cultural changes with the IT service enabled organizations. What is the best method for getting your team’s support as a success factor of project implementation is the paramount need for successful ITSM project. Therefore , study on how “people” impact ITSM business process implementations were started with checking ,“is it true, organization culture influence ITIL project implementations?” , 95% of sample confirmed that organization culture influence ITIL project implementations. Furthermore, Literatures were found “Emphasis and Learning, Openness and Involvement, Fit between requirement and achievement” are the variables (Kampmeier, 1998) of organization culture. Three business cases were analyzed to reveal how organization culture impact on project successes: found nothing but negatively impacted on three business cases! And three project failure due to poor support from the end users!
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    The Pattern of KRAS mutations in metastatic colorectal cancer: a retrospective audit from Sri Lanka
    (Biomed Central, 2017) Sirisena, N.D.; Deen, K.I.; Mandawala, D.E.N.; Herath, P.; Dissanayake, V.H.W.
    Activating mutations in the KRAS gene, found in approximately 53% of metastatic colorectal cancer (mCRC) cases, can render epidermal growth factor receptor (EGFR) inhibitors ineffective. Regional differences in these mutations have been reported. This is the first study which aims to describe the pattern of KRAS mutations in a Sri Lankan cohort of mCRC patients. RESULTS: The KRAS genotypes detected in mCRC patients which have been maintained in an anonymized database were retrospectively analyzed. Of the 108 colorectal tissue samples tested, 25 (23.0%) had KRAS mutations. Overall, there were 68 (63.0%) males and 40 (37.0%) females. Among the KRAS positive cases, there were 14 (56.0%) males and 11 (44.0%) females. Their age distribution ranged from 29 to 85 years with a median age of 61 years. There were 15 patients (60.0%) with point mutations in codon 12 while 10 (40.0%) had a single mutation in codon 13. The most common KRAS mutation identified was p.Gly13Asp (40.0%), followed by p.Gly12Val (24.0%). Other mutations included p.Gly12Cys (12.0%), p.Gly12Ser (12.0%), p.Gly12Asp (8.0%), and p.Gly12Arg (4.0%). The codon 13 mutation was a G>A transition (40.0%), while G>T transversions (32.0%), G>A transitions (24.0%), and G>C transversions (4.0%) were found in the codon 12 mutations. The frequency of KRAS mutations was similar to that reported for Asian patients. However, in contrast to several published studies, the G>A transition in codon 12 (c.35G>A; p.Gly12Asp), was not the most common mutation within codon 12 in our cohort. This may be a reflection of the genetic heterogeneity in the pattern of KRAS mutations in mCRC patients but valid conclusions cannot be drawn from these preliminary findings due to the small size of the study sample.