Browsing by Author "Fernando, M.R."

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Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients
(Elsevier, 1991) Fernando, M.R.; Wickramasinghe, N.; Thabrew, M.I.; Ariyananda, P.L.; Karunanayake, E.H.
Investigations were carried out to evaluate the effects of hot-water extracts of Artocarpus heterophyllus leaves and Asteracanthus longifolia whole plant material on the glucose tolerance of normal human subjects and maturity-onset diabetic patients. The extracts of both Artocarpus heterophyllus and Asteracanthus longifolia significantly improved glucose tolerance in the normal subjects and the diabetic patients when investigated at oral doses equivalent to 20 g/kg of starting material.
Extra pancreatic effects of Hygrophila longifolia
(Informa Healthcare, 1998) Fernando, M.R.; Wickremasinghe, S.M.D.N.; Thabrew, M.I.
The extra-pancreatic effects of the oral hypoglycemic plant Hygrophila longifolia have been investigated in rats. Administration of an aqueous extract of the plant prior to glucose loading resulted in a significant increase in the glycogen content of liver and muscle (by 108.5 + or - 9.5 and 57.8 + or - 4.2 percent, respectively), and a significant increase in triacylglycerol content of adipose tissue (by 10.2 + or - 1.8 percent) in comparison with control rats. However, the plant extract had no effect on the gluconeogenic capacity of the kidney or intestinal glucose absorption. The results obtained in the present study suggest Hygrophila longifolia may exert hypoglycemic action by mechanisms similar to those of the sulphonylureas.
Extra-pancreatic effects contributing to the hypoglycaemic activity of Artocarpus heterophyllus
(University of Colombo, 2001) Fernando, M.R.; Thabrew, M.I.
Hypoglycaemic activity of some medicinal plants in Sri-Lanka
(Elsevier, 1990) Fernando, M.R.; Thabrew, M.I.; Karunanayake, E.H.
Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at +3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at +5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).
A Preliminary investigation of the possible hypoglycaemic activity of Asteracanthus longifolia
(Elsevier, 1989) Fernando, M.R.; Wickramasinghe, N.; Thabrew, M.I.; Karunanayaka, E.H.
Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.
A Social History of Peasants in the Private Lands of Indramayu and Kandanghaur in Java in the Late Nineteenth Century
(University of Kelaniya, 1983) Fernando, M.R.