Bath, P.M.Adami, A.Bereczki, D.Berge, E.Beridze, M.Cala, L.Casado, A.Caso, V.Chang, H.M.Christensen, H.Collins, R.Czlonkowska, A.Dineen, R.A.El Etribi, A.Ghani, A. R.Gommans, J.Koumellis, P.Laska, A. C.Lees, K. R.Navarro, J.Ntaios, G.Ozturk, S.Phillips, S.Pocock, S.Prasad, K.Scutt, P.de Silva, H.A.Szatmari, S.Díez-Tejedor EUtton, S.Wang, Y. J.Wardlaw, J.M.Whynes, D.Wong, L.Woodhouse, LSprigg, N.ENOS Trial Investigators(36)2015-08-272015-08-272014International Journal of Stroke. 2014; 9(6): 711-20.1747-4930 (Print)1747-4949 (Electronic)1747-4930 (Linking)http://repository.kln.ac.lk/handle/123456789/9341Indexed in MEDLINEBACKGROUND: High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. AIMS: ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. METHODS: This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate(a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140–220 mmHg). RESULTS: Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52•3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34(13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. CONCLUSION: ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide.en-USClinical TrialArticlePharmacology