Senarathne, S.Rajapakse, S.de Silva, H.J.Seneviratne, S.Chulasiri, P.Fernando, D.2023-11-092023-11-092023Sri Lankan Journal of Infectious Diseases.2023;13(2):E47 1-52012-8169 (Print)2448-9654 (Electronic)http://repository.kln.ac.lk/handle/123456789/27036Not IndexedGlobal travel and tourism, especially across tropical countries, may lead to importation of malaria and other infectious diseases into Sri Lanka. This case report describes the first co-infection of imported hepatitis E and Plasmodium falciparum malaria in a tourist diagnosed in Sri Lanka. The patient was initially diagnosed with uncomplicated P. falciparum malaria and was started on treatment with oral Artemisinin-based Combination Therapy (ACT). Deterioration of hepatic enzymes and hyperbilirubinaemia despite the rapid parasitological response to antimalarials led to further investigation and diagnosis of co-infecting hepatitis E in this patient. The importance of clinicians being vigilant on travel associated co-infections is highlighted to ensure early diagnosis and better patient management.enPlasmodium falciparumMalariaHepatitis ECo-infectionsHyperbilirubinaemiaArticle