Ranawaka, U.K.Premaratna, R.Kumari, N.B.A.N.A.Wimalarathne, W.R.S.Cooray, D.K.M.M.S.Tissera, W.A.J.N.Kulatunga, A.de Silva, H.J.2015-10-122015-10-122008The Ceylon Medical Journal. 2008; 53(Supplement 1):150009-0875 (Print)http://repository.kln.ac.lk/handle/123456789/10010Oral Presentation Abstract (OP4), 121st Annual Scientific Sessions, Sri Lanka Medical Association, 2008 Colombo, Sri LankaOBJECTIVE: Central nervous system (CNS) infections cause high morbidity and mortality, but data from Sri Lanka are limited. We aimed to describe the pattern of CNS infections presenting to a tertiary care hospital DESIGN, SETTING AND METHODS: We prospectively studied all patients with suspected CNS infection admitted to the medical units of the Colombo North Teaching Hospital over a six-month period. Data were collected on demographic and clinical features, laboratory findings, treatments given and immediate outcome. RESULTS: Fifty patients were studied [64% males, mean age (SD) - 39.4(20.2) years]. Fever (90%), altered consciousness (80%), headache (66%), behavioural change (50%) and neck stiffness (52%) were the commonest findings on presentation. Seizures were seen in 28%, and focal deficits were rare (6%). Blood cultures, blood films for malarial parasites, CSF Gram stains and CSF-eultures were negative. CT scanning was not helpful in diagnosis. A diagnosis of presumed meningitis or encephalitis was made in 36% patients, based on CSF cytology or EEC findings. A definitive aetiological/ microbiological diagnosis was not possible in any patient. All patients were treated with intravenous antibiotics +/- intravenous acyclovir on empiric grounds, without microbiological confirmation. Six patients (12%) died in hospital. CONCLUSIONS: Diagnosis of CNS infections is highly unsatisfactory with the available facilities, even in a tertiary care setting.en-USCNS infectionsArticle