Chandradasa, M.Kuruppuarachchi, C.S.Rathnayake, L.C.Kuruppuarachchi, K.A.L.A.2021-02-182021-02-182020Sri Lanka Journal of Psychiatry.2020; 11(2): 38–39.2579-2008http://repository.kln.ac.lk/handle/123456789/22007Not indexed in MEDLINEABSTRACT: Clozapine is prescribed for resistant schizophrenia. It is usually associated with weight gain. There have been only a few reports of weight loss associated with clozapine treatment and we report two patients from Sri Lanka. The first patient lost 27% of bodyweight on clozapine while the second lost 17%. Both were clinically stable on clozapine, with marked reduction of psychotic symptoms. Adding risperidone helped to regain the lost weight in the described patients. KEYWORDS: Clozapine, Weight, Schizophrenia, Sri Lankaen-USweight lossArticle