Premawardhena, A.de Silver, S.Arambepola, M.Olivieri, N.F.Vichinsky, E.P.Merson, L.Muraco, G.Allen, A.Fisher, C.Peto, T.Weatherall, D.J.2023-07-102023-07-102005Annals of the New York Academy of Sciences.2005;1054(1):33-90077-8923http://repository.kln.ac.lk/handle/123456789/26440indexed in MEDLINE.A long-term observational study of Hb E-beta-thalassemia in Sri Lanka is beginning to define some of the genetic and environmental factors that are responsible for its remarkable phenotypic variability. In this population there is a very small difference between the steady-state hemoglobin levels between the mild and severe phenotypes, and it has been possible to stop transfusion in many of those who have been on long-term treatment of this kind. These preliminary observations, made over the last 7 years, provide directions for future research into this increasingly important disease.enE-beta-thalassemiaArticle