Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/24372
Title: Triple therapy prevention of recurrent intracerebral disease events trial: rationale, design and progress
Authors: Anderson, C.S.
Rodgers, A.
de Silva, H.A.
Martins, S.O.
Klijn, C.J.
Senanayake, B.
Freed, R.
Billot, L.
Arima, H.
Thang, N.H.
Zaidi, W.A.W.
Kherkheulidze, T.
Wahab, K.
Fisher, U.
Lee, T.H.
Chen, C.
Pontes-Neto, O.
Robinson, T.
Wang, J.
Naismith, S.
Song, L.
Schreuder, F.H.
Lindley, R.I.
Woodward, M.
MacMahon, S.
Salman, R.A.
Chow, C.K.
Chalmers, J.
Keywords: Hypertension
Blood pressure lowering
Clinical trial
Intracerebral hemorrhage
Issue Date: 2022
Publisher: Blackwell Publishing
Citation: International Journal of Stroke.2022;17(10):1156-1162. [Epub 2022 Jan 7]
Abstract: Background: Patients who suffer intracerebral hemorrhage (ICH) are at very high risk of recurrent ICH and other serious cardiovascular events. A single-pill combination (SPC) of blood pressure (BP) lowering drugs offers a potentially powerful but simple strategy to optimize secondary prevention. Objectives: The Triple Therapy Prevention of Recurrent Intracerebral Disease Events Trial (TRIDENT) aims to determine the effects of a novel SPC "Triple Pill," three generic antihypertensive drugs with demonstrated efficacy and complementary mechanisms of action at half standard dose (telmisartan 20 mg, amlodipine 2.5 mg, and indapamide 1.25 mg), with placebo for the prevention of recurrent stroke, cardiovascular events, and cognitive impairment after ICH. Design: An international, double-blind, placebo-controlled, randomized trial in adults with ICH and mild-moderate hypertension (systolic BP: 130-160 mmHg), who are not taking any Triple Pill component drug at greater than half-dose. A total of 1500 randomized patients provide 90% power to detect a hazard ratio of 0.5, over an average follow-up of 3 years, according to a total primary event rate (any stroke) of 12% in the control arm and other assumptions. Secondary outcomes include recurrent ICH, cardiovascular events, and safety. Results: Recruitment started 28 September 2017. Up to 31 October 2021, 821 patients were randomized at 54 active sites in 10 countries. Triple Pill adherence after 30 months is 86%. The required sample size should be achieved by 2024.
Description: Indexed in MEDLINE.
URI: http://repository.kln.ac.lk/handle/123456789/24372
ISSN: 1747-4930
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.