Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/2043
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDassanayake, B.K.en_US
dc.contributor.authorSamita, S.en_US
dc.contributor.authorDeen, R.Y.I.en_US
dc.contributor.authorWickramasinghe, N.S.A.en_US
dc.contributor.authorHewavisenthi, J.en_US
dc.contributor.authorDeen, K.I.en_US
dc.date.accessioned2014-10-29T09:32:21Z-
dc.date.available2014-10-29T09:32:21Z-
dc.date.issued2011en_US
dc.identifier.citationThe Ceylon Medical Journal; 56(4): pp.159-61en_US
dc.identifier.issn0009-0875 (Print)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/2043-
dc.description.abstractOBJECTIVES : Local recurrence of rectal cancer reduces quality of life and survival. A multi-factorial linear logistic model was used to analyse risk factors for local recurrence in rectal cancer in patients not receiving preoperative chemo-radiation. METHODS : A case-control study of patients with rectal cancer having surgery with curative intent, between 1996 and 2008. Eighteen putative risk factors for local recurrence were subjected to uni-variate analysis. Significant factors were selected for multi-factorial analysis. RESULTS : Twenty-one patients with local recurrence (cases) and 78 controls were selected. Uni-variate analysis showed significant associations with recurrence for nodal stage (N) (p=0.027), metastasis (M) (p=0.009), adjuvant chemotherapy (p=0.039), positive resection margin (R) (p=0.018) and American Joint Committee for Cancer (AJCC) tumours above stage II (p=0.043). Significant uni-variate odds ratios (OR) were obtained for the same factors. Two linear logistic models were fitted as (1) N, M, R1 status and adjuvant chemotherapy and (2) AJCC stage, R1 status and adjuvant chemotherapy. From both models, the only factor significantly associated (p≤0.01) with local recurrence was found to be a positive resection margin (OR 4.81 and 5.51 respectively). CONCLUSIONS: A positive resection margin is the single factor affecting local recurrence of rectal cancer in patients not receiving neo-adjuvant therapy.-
dc.publisherSri Lanka Medical Associationen_US
dc.titleLocal recurrence of rectal cancer in patients not receiving neoadjuvant therapy - the importance of resection marginsen_US
dc.typeArticleen_US
dc.identifier.departmentSurgeryen_US
dc.identifier.departmentPahologyen_US
dc.creator.corporateauthorSri Lanka Medical Associationen_US
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.