Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/17824
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dc.contributor.authorWarnakulasuriya, T.
dc.contributor.authorWilliams, S.
dc.contributor.authorDabarera, M.
dc.contributor.authorRodrigo, K.
dc.contributor.authorWeerakkody, T.
dc.contributor.authorWickremasinghe, R.
dc.date.accessioned2017-10-12T14:44:21Z
dc.date.available2017-10-12T14:44:21Z
dc.date.issued2017
dc.identifier.citationMutagenesis. 2017;32(5):511-516en_US
dc.identifier.issn0267-8357 (Print)
dc.identifier.issn1464-3804 (Electronic)
dc.identifier.issn0267-8357 (Linking)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/17824
dc.descriptionIndexed in MEDLINEen_US
dc.description.abstractLanka Mineral Sands Ltd (LMS), a government-owned company, has been mining mineral sands including monazite which contains thorium (Th) at Pulmoddai, Sri Lanka since 1957. Th emits alpha particles on decay and gamma rays are emitted by the daughter products. The cytokinesis-blocked micronucleus (MN) assay is popular for large scale radiation exposure studies as it is an easy, fast and reliable method of biodosimetry. The objective of the study was to determine the frequency of micronuclei among persons residing in the vicinity of LMS. A cross-sectional study was conducted from November 2012 to September 2016 among persons 35-45 years of age to evaluate the frequency of micronuclei in peripheral blood lymphocytes. Fifty-three employees of LMS factory, 25 residents within 5 km from LMS, 25 residents 20-25 km from LMS and 29 residents from >50 km away from LMS were included in the study. The highest median frequency of micronuclei per 1000 binucleated (BN) cells was in the group residing within 5 km from LMS with a median (IQ range) of 0.67 (0.17-2.17). The median (IQ range) of MN frequency of employees of LMS, residents 20-25 km from LMS and residents >50 km from LMS were 0.66 (0.16-1.16), 0.33 (0.00-0.67) and 0.33 (0.33-0.67), respectively. There was no significant difference in the MN frequency between employees of LMS and the group residing within 5 km from LMS. Being a resident of Pulmoddai and being exposed to X-rays were significant predictors of MN frequency. Persons residing within 5 km from LMS had a higher risk of MN formation irrespective of being employed at LMS.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.subjectEnvironmental Healthen_US
dc.titleFrequency of micronuclei among persons resident in the vicinity of a mineral sand processing factory in Pulmoddai, Sri Lankaen_US
dc.typeArticleen
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