Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/12796
Title: Hepatocellullar carcinoma: the Sri Lankan perspective
Authors: Siriwardana, R.
Keywords: Carcinoma, Hepatocellular
Sri Lanka
Issue Date: 2016
Publisher: Faculty of Medicine, University of Kelaniya, Sri Lanka
Citation: Proceedings of the 25th Anniversary International Scientific Conference. Faculty of Medicine, University of Kelaniya; 2016: 49
Abstract: Ragama has become a center of excellence in the management of hepatocellular carcinoma (HCC). Since 2012 we have managed approximately 500 patients with HCC referred from different parts of the country. Sri Lanka appears to have an unique pattern of disease not seen in any other part of the world. The large majority of HCC in our population is related to non-alcoholic fatty liver disease (NAFLD). With novel treatment of hepatitis C and hepatitis B vaccination globally, it is predicted that NAFLD will be the leading cause of liver disease in the future. In Sri Lanka with rapidly rising prevalence of NAFLD, liver cancer will also continue to rise. In this background of NAFLD, diffuse variant of HCC has higher incidence in our patients. Consumption of alcohol is a risk factor to develop diffuse type HCC. Diffuse type HCC has a grave prognosis. A significant proportion of NAFLD patients develop HCC in non-cirrhotic liver. This raises the need to screen at-risk groups in the future. These non-cirrhotic hepatomas are larger in size and have a better prognosis than others. Alpha-feto protein is an unreliable marker in the assessment of our patients with NAFLD induced HCC. Our cohort of patients is an excellent sample to study the future pattern of HCC worldwide.
Description: Symposium E (SYM E): Liver disease and metabolic syndrome in Sri Lanka - 25th Anniversary International Scientific Conference, 6-8 April 2016, Faculty of Medicine,University of Kelaniya, Sri Lanka
URI: http://repository.kln.ac.lk/handle/123456789/12796
Appears in Collections:25th Anniversary International Scientific Conference-2016

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