Unfolded protein response pathway in leishmaniasis: A review

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Date

2023

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species.

Description

Indexed in MEDLINE

Keywords

Leishmania species, activating transcription factor 6, endoplasmic reticulum, inositol requiring enzyme 1, leishmaniasis, protein kinase RNA-like ER kinase, unfolded protein response

Citation

Parasite Immunology.2023 : e13009 (Online ahead of print.)

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Review

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