Worsening cholestasis and possible cefuroxime-induced liver injury following "successful" therapeutic endoscopic retrograde cholangiopancreatography for a distal common bile duct stone: a case report
| dc.contributor.author | Niriella, M.A. | |
| dc.contributor.author | Kumarasena, R.S. | |
| dc.contributor.author | Dassanayake, A.S. | |
| dc.contributor.author | Pathirana, A. | |
| dc.contributor.author | de Silva, H.J. | |
| dc.date.accessioned | 2016-12-28T06:01:33Z | |
| dc.date.available | 2016-12-28T06:01:33Z | |
| dc.date.issued | 2016 | |
| dc.description | Indexed in MEDLINE | en_US |
| dc.description.abstract | BACKGROUND: Cefuroxime very rarely causes drug-induced liver injury. We present a case of a patient with paradoxical worsening of jaundice caused by cefuroxime-induced cholestasis following therapeutic endoscopic retrograde cholangiopancreatography for a distal common bile duct stone. CASE PRESENTATION: A 51-year-old, previously healthy Sri Lankan man presented to our hospital with obstructive jaundice caused by a distal common bile duct stone. Endoscopic retrograde cholangiopancreatography with stone extraction, common bile duct clearance, and stenting failed to improve the cholestasis, with paradoxical worsening of his jaundice. A liver biopsy revealed features of drug-induced intrahepatic cholestasis. Although his case was complicated by an episode of cholangitis, the patient made a complete recovery in 4 months with supportive treatment and withdrawal of the offending drug. CONCLUSIONS: This case highlights a very rare drug-induced liver injury caused by cefuroxime as well as our approach to treating a patient with paradoxical worsening of jaundice after therapeutic endoscopic retrograde cholangiopancreatography. | en_US |
| dc.identifier.citation | Journal of Medical Case Reports. 2016; 10(1): 371 | en_US |
| dc.identifier.issn | 1752-1947 (Electronic) | |
| dc.identifier.issn | 1752-1947 (Linking) | |
| dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/15653 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | BioMed Central | en_US |
| dc.subject | cefuroxime-induced liver injury | en_US |
| dc.title | Worsening cholestasis and possible cefuroxime-induced liver injury following "successful" therapeutic endoscopic retrograde cholangiopancreatography for a distal common bile duct stone: a case report | en_US |
| dc.type | Article | en_US |