Prevalence and intensity of Wuchereria bancrofti antigenaemia in Sri Lanka by Og4C3 ELISA using filter paper-absorbed whole blood
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Date
2002
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
In Sri Lanka 2741 people from Matara, an endemic area for Wuchereria bancrofti, were examined in 1996/97 for microfilariae by 60-microL blood smear and for circulating filarial antigens by Og4C3 ELISA using filter paper-absorbed whole blood. The overall prevalence of microfilaraemia was 3.4%, and that of antigenaemia 14.4%. The prevalence of antigen-positive and microfilaria-negative people was 11.3%. Analysed by age-group,antigenaemia prevalence was similar in all groups, and the average number of antigen units was already very high in the age-group < 10 years, indicating that the infection started in early childhood. Among those who were antigen positive, the microfilaria prevalence was lower in females than in males. Diethylcarbamazine treatment eliminated microfilariae in 78% of the positives. However, 17 months after the treatment, antigenaemia was still positive in 76% of those who were parasitologically cured.
Description
Indexed in MEDLINE
Keywords
Filariasis, Wuchereria bancrofti, Filariasis-epidemiology, Sri Lanka-epidemiology, Wuchereria bancrofti-immunology, Antigens, Helminth-blood, Prevalence
Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. 2002; 96(1): pp. 41-45