Assessing the synaptic transmission speed (ms) and action potential frequency (Hz) of water in relation to its behaviour in theoretical and computational neuroscience field

Abstract

The study quantified water concentration (%) effects on synaptic transmission speed (ms) and action potential (AP) frequency (Hz) in silico. NEURON-simulated pyramidal neuron under controlled water levels (40–100%) was undertaken. Linear regression (SciPy) was applied to analyzed relationships. The result indicated that synaptic delay increased linearly with water reduction: slope = -0.012 ms/% (R²=0.99, F(1,2)=172.5, p <0.01). AP frequency decreased linearly: slope = -0.225 Hz/% (R² = 0.99, F(1,2) = 452.3, p <0.01). Mean ± SEM at 70% water: synaptic delay = 1.43±0.129 ms; AP frequency = 39.75±2.07 Hz. The study concluded that; water concentration directly governs neural signaling velocity and firing rates with near-perfect linear predictability.