Concentrations of interleukin 6 and tumour necrosis factor in serum and stools of children with Shigella dysenteriae 1 infection

dc.contributor.authorde Silva, D.G.H.en_US
dc.contributor.authorMendis, L.N.en_US
dc.contributor.authorSheron, N.en_US
dc.contributor.authorAlexander, G.J.en_US
dc.contributor.authorCandy, D.C.en_US
dc.contributor.authorChart, H.en_US
dc.contributor.authorRowe, B.en_US
dc.creator.corporateauthorBritish Medical Associationen_US
dc.creator.corporateauthorBritish Society of Gastroenterologyen_US
dc.date.accessioned2014-10-29T09:10:46Z
dc.date.available2014-10-29T09:10:46Z
dc.date.issued1993en_US
dc.descriptionIndexed in MEDLINE
dc.description.abstractSerum interleukin 6 (IL-6) and tumour necrosis factor (TNF) were measured in children with dysentery during an epidemic caused by Shigella dysenteriae 1. IL-6 and TNF were also measured in fresh stool filtrates from children with acute gastroenteritis. The median serum IL-6 concentration was raised significantly in the children with complications (haemolytic uraemic syndrome, leukemoid reaction, thrombocytopenia, thrombocytosis, and severe colitis lasting more than one week) during the first week (n = 18, 9-7728 pg/ml; median 107) and in the second week (n = 13, 5-312 pg/ml; median 77), compared with convalescent sera (n = 10, < 3-85 pg/ml; median 39; p < 0.02 and < 0.05 respectively). The median IL-6 concentration during the first week was significantly higher in the group with complicated disease than in those with no complications (n = 8, < 3-37 pg/ml; median 5; p < 0.001). Although serum TNF concentrations were significantly raised in the complicated group during the first and second weeks of the illness and in the uncomplicated group compared with convalescence, there was no significant difference in the TNF concentrations between the complicated and uncomplicated groups. IL-6 was detectable in stool filtrates from eight of 13 children with S dysenteriae 1 infection and four of eight children with S flexneri infection. It was not detectable in Cryptosporidia, rotavirus, or adenovirus infections, those with pathogen-negative acute diarrhoea or controls. Seven of 13 children with S dysenteriae 1 and three of nine children with S flexneri infections had TNF detectable in stools. None of the children with Salmonella, Cryptosporidia, rotavirus of children with pathogen-negative diarrhoea and controls had detectable TNF in stool filtrates. It is postulated that the local and generalised vasculitis observed in shigellosis may be related to a direct effect of Shiga toxin on endothelial cells or caused by cytokine production stimulated by endotoxin, or both.en_US
dc.identifier.citationGut. 1993; 34(2): pp.194-198en_US
dc.identifier.departmentPaediatricsen_US
dc.identifier.issn0017-5749 (Print)en_US
dc.identifier.issn1468-3288 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/1178
dc.publisherBritish Medical Assosiationen_US
dc.subjectDiarrhea
dc.subjectDysentery, Bacillary-complications
dc.subjectDysentery, Bacillary-immunology
dc.subjectFeces-chemistry
dc.subjectInterleukin-6-blood
dc.subjectInterleukin-6-metabolism
dc.subjectShigella dysenteriae
dc.subjectShigella flexneri
dc.subjectTumor Necrosis Factor-alpha-metabolism
dc.titleConcentrations of interleukin 6 and tumour necrosis factor in serum and stools of children with Shigella dysenteriae 1 infectionen_US
dc.typeArticleen_US

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