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The value of BRUNT scoring in predicting the short term outcome of non-alcoholic

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dc.contributor.author Hewavisenthi, S.J.de S.
dc.contributor.author Pathmeswaran, A.
dc.contributor.author de Silva, H.J.
dc.date.accessioned 2015-10-05T03:46:31Z
dc.date.available 2015-10-05T03:46:31Z
dc.date.issued 2005
dc.identifier.citation The Ceylon Medical Journal. 2005; 50(Supplement 1):6 en_US
dc.identifier.issn 0009-0875 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/9910
dc.description Oral Presentation Abstract (OP1), 118th Annual Scientific Sessions, Sri Lanka Medical Association, 2005 Colombo, Sri Lanka en_US
dc.description.abstract BACKGROUND: BRUNT scoring is currently used in the grading and staging of liver biopsies in non¬alcoholic steatohepatitis (NASH,). Its value in predicting the outcome of patients following modifications in lifestyle, the cornerstone of management in NASH, needs evaluation. Objectives: To determine whether BRUNT grades correlate with aspartate transammase (AST) and alanine transaminase (ALT) levels, and outcome following lifestyle modifications in NASH. METHOD: In aprospective study from May 1999 to May 2003 the biopsies of 79 patients diagnosed as having NASH were assigned 3 necromfiamrnatory grades based on the BRUNT system. The mean serum transaminase values at presentation for each necroinflammatory grade were compared using ANOVA. 77/79 patients were given advice on lifestyle modifications and followed up for a median 2.5 years. The time taken for serum transaminases to return to normal was correlated with the necroinflammatory grades, AST and ALT values at presentation. RESULTS: The mean AST and ALT values (IU/L) in the three necroinflammatory grades were - grade 1:62.4 and 102:1, grade 2: 87.6 and 139.4 and grade 3: 90.9 and 164.5. There was a significant difference in the AST and ALT values between grades 1 and 2, and grades 1 and 3, but not between grades 2 and 3. In 51/77 patients serum transaminases returned to normal levels after a median 6 months (range 3-14 months). There was no significant correlation between the time taken for serum transaminases to return to normal and the transaminase values or necroinflammatory grades at presentation. CONCLUSION: BRUNT grading correlates with both AST and ALT levels. However, neither necroinflammatory grades nor serum transaminase values at first presentation are predictors of the duration to normalisation of liver enzymes in NASH patients managed with lifestyle modifications, en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject BRUNT scoring en_US
dc.title The value of BRUNT scoring in predicting the short term outcome of non-alcoholic en_US
dc.type Conference Abstract en_US


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