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Regional Concentrations of Cyclic Nucleotides After Experimental Brain Injury

Show simple item record Dhillon, H.S. en_US Yang, L. en_US Jayawardena, B.M. en_US Dempsey, R.J. en_US Prasad, M.R. en_US 2014-11-19T04:40:11Z 2014-11-19T04:40:11Z 1995
dc.identifier.citation Regional concentrations of cyclic nucleotides after experimental brain injury, H.S. Dhillon, L. Yang, B.Padmaperuma, R.J.Dempsey, and M.R.Prasad, J.Neurotrauma Dec. 12 (6) 1035-43 1995.
dc.description.abstract Regional concentrations of lactate, glucose, cAMP, and cGMP were measured after lateral fluid percussion brain injury in rats. At 5 min after injury, while tissue concentrations of lactate were elevated in the cortices and hippocampi of both the ipsilateral and contralateral hemispheres, those of glucose were decreased in these brain regions. By 20 min after injury, increases of lactate concentrations and decreases of glucose concentrations were observed only in the cortices and in the hippocampus of the ipsilateral hemisphere. Whereas the cAMP concentrations were unchanged in the cortices and hippocampi of the ipsilateral and contralateral hemispheres at 5 min after injury, decreases were found in the injured cortex and ipsilateral hippocampus at 20 min after injury. The tissue concentrations of cGMP were found to be elevated only in the ipsilateral hippocampus at 5 min after injury. The present observation that tissue glucose decreases in the injured cortex and the ipsilateral hippocampus are consistent with the published findings of increased hyperglycolysis and oxidative metabolism in brain immediately after injury. The present findings that the concentrations of cAMP and cGMP change in the cortex and hippocampus provide biochemical evidence for the neurotransmitter's surge after brain injury. en_US
dc.publisher Journal of Neurotrauma en_US
dc.title Regional Concentrations of Cyclic Nucleotides After Experimental Brain Injury
dc.type article en_US
dc.identifier.department Biochemistry en_US

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