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Changes in 1,4,5 inositol triphosphate receptors following experimental brain injury

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dc.contributor.author Jayawardena, B.M. en_US
dc.contributor.author Dhillon, H.S. en_US
dc.contributor.author Carbary, T. en_US
dc.contributor.author Prasad, M.R. en_US
dc.date.accessioned 2014-11-19T04:40:11Z
dc.date.available 2014-11-19T04:40:11Z
dc.date.issued 1995
dc.identifier.citation Changes in 1,4,5 inositol triphosphate receptors following experimental brain injury, B.Padmaperuma, H.S.Dhillon, Timothy Carbary and M.R. Prasad, Neurosci. Res. Commun., 16, 121-127 ,1995.
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/3778
dc.identifier.uri http://serials.unibo.it/cgi-ser/start/it/spogli/df-s.tcl?prog_art=2608738&language=ITALIANO&view=articoli
dc.description.abstract Inositol 1,4,5-tris phosphate (IP3), a cellular second messenger of excitatory neurotransmitter system, by interacting with membrane IP3 receptor can mobilize calcium from internal stores. Regional binding properties of IP3 receptor were measured after lateral fluid percussion (FP) brain injury in rats. At 5 min postinjury, a significant decrease in the IP3 receptor density was found only in the ipsilateral left hippocampus. At 20 min after injury, significant decreases were observed in both the receptor density and the half maximal reduction of IP3, binding in both the injured left cortex and ipsilateral hippocampus. These findings suggest that increases of ligand affinity to the IP3 receptor after brain injury. This change in the IP3 receptor in concert with the increased IP3 (21) may facilitate a possible IP3 action of calcium mobilization in the brain regions that undergo neuronal cell loss after brain injury. en_US
dc.publisher Neuroscience research communications en_US
dc.title Changes in 1,4,5 inositol triphosphate receptors following experimental brain injury
dc.type article en_US
dc.identifier.department Biochemistry en_US


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