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Chronic myeloid leukaemia with generalized lymphadenopathy – a high risk category

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dc.contributor.author Prasanni, W.D.D.
dc.contributor.author Williams, H.S.A.
dc.contributor.author Costa, Y.J.
dc.contributor.author Dissanayake, T.
dc.date.accessioned 2024-03-04T06:20:44Z
dc.date.available 2024-03-04T06:20:44Z
dc.date.issued 2022
dc.identifier.citation The Sri Lanka Journal of Haematology.2022;14(1):19-23 en_US
dc.identifier.issn 1391-7919 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/27627
dc.description Not Indexed in MEDLINE en_US
dc.description.abstract Chronic myeloid leukaemia (CML) presenting with generalized lymphadenopathy is an uncommon manifestation of CML. Lymphadenopathy in these patients could be due to extramedullary involvement by myeloid cells with all stages of maturation, blast infiltration, co-existing lymphoproliferative disorder or reactive lymphadenopathy. We report a case of a 38-year-old male with CML in chronic phase and generalized lymphadenopathy at diagnosis. He transformed to blast crisis within 14 weeks of diagnosis despite tyrosine kinase inhibitor (TKI) therapy. This case indicates that CML patients with lymphadenopathy are at high risk of disease progression and early blast transformation and therefore candidates for aggressive treatment. en_US
dc.language.iso en en_US
dc.publisher The Sri Lanka College of Haematologists en_US
dc.subject Myeloid leukaemia en_US
dc.title Chronic myeloid leukaemia with generalized lymphadenopathy – a high risk category en_US
dc.type Article en_US


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