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Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis

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dc.contributor.author Fernando, N.
dc.contributor.author de Silva, R.
dc.contributor.author Hadunnetti, S.M.
dc.contributor.author Karunanayake, L.
dc.contributor.author de Silva, N.L.
dc.contributor.author de Silva, H.J.
dc.contributor.author Rajapakse, S.
dc.contributor.author Premawansa, S.
dc.date.accessioned 2018-07-05T03:50:39Z
dc.date.available 2018-07-05T03:50:39Z
dc.date.issued 2018
dc.identifier.citation Antimicrobial agents and chemotherapy.2018;62(5). pii: e02312-17 en_US
dc.identifier.issn 0066-4804 (Print)
dc.identifier.issn 1098-6596 (Electronic)
dc.identifier.issn 0066-4804 (Linking)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/18919
dc.description Indexed In MEDLINE en_US
dc.description.abstract The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (P = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses (P < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = -0.315; P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis. en_US
dc.language.iso en_US en_US
dc.publisher American Society for Microbiology en_US
dc.subject ceftriaxone en_US
dc.title Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis en_US
dc.type Article en_US


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