Digital Repository

Aetiology of cirrhosis in a tertiary referral centre in Sri Lanka

Show simple item record

dc.contributor.author Dassanayake, A.S. en_US
dc.contributor.author Mettananda, K.C.D. en_US
dc.contributor.author de Silva, A.P. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2015-12-25T00:46:22Z en_US
dc.date.available 2015-12-25T00:46:22Z en_US
dc.date.issued 2005 en_US
dc.identifier.citation Liver International. 2005; 25(6) : 1291-92 en_US
dc.identifier.issn 1478-3223 (Print) en_US
dc.identifier.issn 1478-3231 (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/10962 en_US
dc.description Poster Session Abstract (No.117), 15th Asian Pacific Association for the Study of the Liver(APASL), 2004, Bali Indonesia en_US
dc.description.abstract INTRODUCTION: Alcoholic liver disease is widely believed to be the commonest cause of cirrhosis in Sri Lanka. However, with the rising prevalence of obesity and diabetes, non-alcoholic steatohepatitis (NASH) is increasingly being diagnosed. Despite being situated in an intermediate to high transmission region, the prevalence of both hepatitis B (o2%) and C ( 1%) is low in our population. AIMS: To study the aetiology of cirrhosis in a tertiary referral centre in Sri Lanka. METHODS: We analysed the database of outpatients with cirrhosis maintained since 2001, reviewing records with regard to aetiology. A diagnosis of cirrhosis was established on clinical, biochemical and radiological evidence, and confirmed histologically when required. A detailed alcohol and drug history was obtained from all cirrhotic patients. Hepatitis B and C serology, iron and copper studies, and an autoimmune screen were also performed. RESULTS: Records of 101 patients were analysed (male:female 5 78:23, mean age 38.3 years (SD 17.5)). The aetiology of cirrhosis was as follows: alcohol 64 patients (63.4%, male:female 5 60:4), cryptogenic 24 (23.8%, male:female 5 12:12), chronic hepatitis B four (all males), autoimmune hepatitis four (all females), Wilson’s disease two (both females), previously diagnosed NASH two (one male, one female), and chronic hepatitis C one (male). The prevalence of diabetes was 45% among patients with cryptogenic cirrhosis compared to 27% among patients with other causes. CONCLUSIONS: Alcohol remains the commonest cause of cirrhosis in our patients. Cryptogenic cirrhosis was the second commonest cause overall, and the commonest among females. The high prevalence of diabetes among patients with cryptogenic cirrhosis suggests an aetiology of previously undetected NASH. en_US
dc.language.iso en_US en_US
dc.publisher Wiley Blackwell Scientific Publications en_US
dc.subject Liver Cirrhosis en_US
dc.subject Liver Cirrhosis-etiology en_US
dc.title Aetiology of cirrhosis in a tertiary referral centre in Sri Lanka en_US
dc.type Conference Abstract en_US
dc.creator.corporateauthor International Association for the Study of the Liver en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

  • Conference Papers
    Papers presented at local and international conferences by the Staff of the Faculty of Medicine

Show simple item record

Search Digital Repository


Browse

My Account