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Item Medium composition affects the heavy metal tolerance of microalgae: a comparison(Journal of Applied Phycology, 2021, 2021) Rathnayake, I.V.N.; Megharaj, M.; Beer, M.; Naidu, RaviTolerance of the three metals cadmium (Cd), copper (Cu), and zinc (Zn) by four microalgal species was investigated in three different culture media available in the literature together with a modified version in order to ...Item Heavy metal toxicity to bacteria – Are the existing growth media accurate enough to determine heavy metal toxicity?(Chemosphere, 2021, 2021) Rathnayake, I.; Megharaj, M.; Krishnamurti, G; Bolan, N. S.; Naidu, R.A new minimal medium was formulated considering the limitations of the existing media for testing heavy metal sensitivity to bacteria. Toxicity of cadmium and copper to three bacteria was investigated in the new medium and ...Item Effects of Low-Cost Organic Fertilizer Derived from Invasive Alien Plants and Shade on Growth Performances and Yield of Aloe vera (L.) Burm.f.(Institute of Biology, Sri Lanka, 2021, 2021) Bandaranayake, A.R.B.W.M.C.D.; Ratnayake, R.M.C.S.Aloe vera is a popular herb for cosmetic and medicinal industries at the global level. The study was conducted to evaluate the effects of organic liquid fertilizer (OLF) from invasive alien plant species (IAPS), MimosaItem Synthesis, In Silico Studies, and Evaluation of Syn and Anti Isomers of N-Substituted Indole-3-carbaldehyde Oxime Derivatives as Urease Inhibitors against Helicobacter pylori(molecules, 2021, 2021) Kalatuwawege, I.P.; Gunaratna, M.J.; Udukala, D.N.• Gastrointestinal tract infection caused by Helicobacter pylori is a common virulent disease found worldwide, and the infection rate is much higher in developing countries than in developed ones. In the pathogenesis of H. pylori in the gastrointestinal tract, the secretion of the urease enzyme plays a major role. Therefore, inhibition of urease is a better approach against H. pylori infection. In the present study, a series of syn and anti isomers of N-substituted indole-3-carbaldehyde oxime derivatives was synthesized via Schiff base reaction of appropriate carbaldehyde derivatives with hydroxylamine hydrochloride. The in vitro urease inhibitory activities of those derivatives were evaluated against that of Macrotyloma uniflorum urease using the modified Berthelot reaction. Out of the tested compounds, compound 8 (IC50 = 0.0516 0.0035 mM) and compound 9 (IC50 = 0.0345 0.0008 mM) were identified as the derivatives with potent urease inhibitory activity with compared to thiourea (IC50 = 0.2387 0.0048 mM). Additionally, in silico studies for all oxime compounds were performed to investigate the binding interactions with the active site of the urease enzyme compared to thiourea. Furthermore, the drug-likeness of the synthesized oxime compounds was also predicted.Item Green Bond: A new debt instrument for environmental resilient projects(Environmental Monitoring and Management, University of Peradeniya, Sri Lanka, 2021, 2021) Nanayakkara, K.G.M.; Colombage, SisiraItem Sensitivity of freshwater organisms to cadmium and copper at tropical temperature exposures: Derivation of tropical freshwater ecotoxicity thresholds using species sensitivity distribution analysis(Ecotoxicology and Environmental Safety, 2021, 2021) Arambawatta Lekamge, S. H.; Pathiratne, A.; Rathnayake, I.V.N.Tropical freshwater ecosystems are increasingly influenced by chemical stressors including heavy metals posing threats to biodiversity. Adequate ecotoxicity data are not available for native tropical freshwater species for ...Item Green fluorescent protein based whole cell bacterial biosensor for the detection of bioavailable heavy metals in soil environment(Environmental Technology & Innovation, 2021, 2021) Rathnayake, I.; Megharaj, M; Naidu, R.A Green fluorescent protein (GFP) based whole cell bacterial biosensor was prepared using a bacterial strain sensitive to several heavy metals in order to detect bioavailable heavy metals in soils. The transformant, named ...Item The Groundwater Geochemistry and the Human Health Risk Assessment of Drinking Water in anArea with aHighPrevalence of Chronic Kidney Disease of Unknown Etiology (CKDu), Sri Lanka(Journal of Chemistry, 2021, 2021) Botheju, W. S. M; Liyanage, J. A; Kannangara, S. D. P; Corchado, J.Chronic kidney disease of unknown etiology (CKDu) has become an alarming health issue in Sri Lanka. ,e disease is more notable among farming communities and people who consume groundwater as their main source of drinking ...Item Sensitivity of Four Cyanobacterial Isolates from Tropical Freshwaters to Environmentally Realistic Concentrations of Cr6+, Cd2+ and Zn2+(Bulletin of Environmental Contamination and Toxicology volume, 2021, 2021) Munagamage, Thilini; Rathnayake, I. V. N; Pathiratne, A; Megharaj, MallavarapuSensitivity of four tropical cyanobacteria viz. Coelosphaerium sp., Synechococcus sp., Oscillatoria sp. and Chroococcus sp. to environmentally relevant concentrations of Cr6+, Cd2+ and Zn2+was assessed based on fluorescence ...Item Toward Sustainable Environmental Quality: Priority Research Questions for Asia(Environmental Toxicology and Chemistry, 2021, 2021) Kenneth, M.Y.; Leung;, Katie W.Y.; Yeung;, Jing; You; Kyungho, Choi; Xiaowei, Zhang; Ross, Smith; Guang-Jie; Zhou; Mana, M.N; Yung, Carlos Arias-Barreiro; Youn-Joo An, S; Rebekah, Burket; Robert, Dwyer; Nathalie, Goodkin; Yii Siang; Hii;, Tham; Hoang;, Chris; Humphrey;, Chuleemas Boonthai; Iwai;, Seung-Woo; Jeong;, Guillaume; Juhel;, Ali; Karami;, Katerina Kyriazi; Lee;, Bin-Le; Lin; Ben, Lu; Patrick, Martin; Mae Grace; Nillos;, Katharina; Oginawati; Rathnayake, I.V.N; Risjani, Mohammad Yenny;; Shoeb;, Chin Hon; Tan; Maria Claret; Tsuchiya; Gerald T; Ankley;, Alistair; B.A; Boxall, Murray A; Rudd, Bryan W.Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where influences of global megatrends are extensive and numerous stresses to environmental quality exist. ...