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Item Medium composition affects the heavy metal tolerance of microalgae: a comparison(Journal of Applied Phycology, 2021, 2021) Rathnayake, I.V.N.; Megharaj, M.; Beer, M.; Naidu, RaviTolerance of the three metals cadmium (Cd), copper (Cu), and zinc (Zn) by four microalgal species was investigated in three different culture media available in the literature together with a modified version in order to ...Item Synthesis, In Silico Studies, and Evaluation of Syn and Anti Isomers of N-Substituted Indole-3-carbaldehyde Oxime Derivatives as Urease Inhibitors against Helicobacter pylori(molecules, 2021, 2021) Kalatuwawege, I.P.; Gunaratna, M.J.; Udukala, D.N.• Gastrointestinal tract infection caused by Helicobacter pylori is a common virulent disease found worldwide, and the infection rate is much higher in developing countries than in developed ones. In the pathogenesis of H. pylori in the gastrointestinal tract, the secretion of the urease enzyme plays a major role. Therefore, inhibition of urease is a better approach against H. pylori infection. In the present study, a series of syn and anti isomers of N-substituted indole-3-carbaldehyde oxime derivatives was synthesized via Schiff base reaction of appropriate carbaldehyde derivatives with hydroxylamine hydrochloride. The in vitro urease inhibitory activities of those derivatives were evaluated against that of Macrotyloma uniflorum urease using the modified Berthelot reaction. Out of the tested compounds, compound 8 (IC50 = 0.0516 0.0035 mM) and compound 9 (IC50 = 0.0345 0.0008 mM) were identified as the derivatives with potent urease inhibitory activity with compared to thiourea (IC50 = 0.2387 0.0048 mM). Additionally, in silico studies for all oxime compounds were performed to investigate the binding interactions with the active site of the urease enzyme compared to thiourea. Furthermore, the drug-likeness of the synthesized oxime compounds was also predicted.Item Production trends and technical efficiencies of culture‐based fisheries in five tropical irrigation reservoirs: A case study from Sri Lanka(Fisheries Management and Ecology, 2020) Pushpalatha, K.B.C.; Kularatne, M.G.; Chandrasoma, J.; Amarasinghe, U.S.Culture‐based fisheries (CBF) are increasingly accepted as strategies for enhancing inland fisheries, especially in tropical Asia. In Sri Lanka, CBF development in irrigation reservoirs has gained momentum due to concerted efforts of government fisheries authorities for inland fisheries enhancement. In the present study, production trends of five irrigation reservoirs of Sri Lanka before and after the introduction of CBF were investigated and apparently optimal CBF yields were not realised. Hence, the stochastic frontier production function (SFPF) was employed to quantify technical efficiencies (TE) of CBF. For each reservoir, annual averages of input data from 2005 to 2018 (14 years) were used in the TE analysis. Hence, total sample size for estimation of SFPF was 70. Although CBF production gradually increased in all five reservoirs from 2005 to 2018, there were substantial variations of total fish production across the reservoirs. The SFPF indicated that CBF production could be further increased through more efficient management of inputs (i.e. number of fishers, mean number of fishing days per year and stocking density). https://onlinelibrary.wiley.com/doi/full/10.1111/fme.12460?af=R