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Browsing by Subject "Haemoglobin"

Browsing by Subject "Haemoglobin"

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  • An attempt to study the behavior of plasma Hemoglobin in post transfusion iron chelated state in beta thalassemia major patients at Thalassemia Unit Kurunegala 
    Adikari, A.A.S.R.; Nawarathna, N.H.LA.; Fernando, K.M.I.; Abeypala, B.M.P.P.M.; Kottahachchi, D.U.; Gunathilaka, S. (Faculty of Medicine, University of Kelaniya, Sri Lanka, 2021)
    Introduction: Beta thalassemia major (pTM) patients require regular blood transfusions due to improper synthesis of normal hemoglobin. Objectives: The aim of this study is to make an attempt to examine the behavior of ...
  • Direct correction of haemoglobin E β-thalassaemia using base editors 
    Badat, M.; Ejaz, A.; Hua, P.; Rice, S.; Zhang, W.; Hentges, L.D.; Fisher, C.A.; Denny, N.; Schwessinger, R.; Yasara, N.; Roy, N.B.A.; Issa, F.; Roy, A.; Telfer, P.; Hughes, J.; Mettananda, S.; Higgs, D.R.; Davies, J.O.J. (Nature Pub. Group, 2023)
    Haemoglobin E (HbE) β-thalassaemia causes approximately 50% of all severe thalassaemia worldwide; equating to around 30,000 births per year. HbE β-thalassaemia is due to a point mutation in codon 26 of the human HBB gene ...
  • Global Burden of Haemoglobin Disorders 
    Rees, D.C. (Faculty of Medicine, University of Kelaniya, Sri Lanka, 2016)
    OBJECTIVES: 1. To describe the world distribution of haemoglobin disorders 2. To describe the health burden of haemoglobin disorders Haemoglobin disorders are the commonest, severe inherited disorders in the world, ...
  • Haemoglobin, BMI and productivity of apparel factory workers 
    de Alwis, R.A.S.D.; de Costa, M.C.N.; de Zoysa, E.C.E.S.; Dias, I.D.A.P.M.; de Silva, N.D.D.N.; Williams, H.S.A.; Pathmeswaran, A. (Sri Lanka Medical Association, 2018)
    INTRODUCTION AND OBJECTIVES: Apparel exports bring the largest amount of foreign exchange in to the country. Thus the productivity of the apparel sector is an important factor in the -economic development of Sri Lanka. ...
  • Studies on Haemoglobin E β-thalassaemia in Sri Lanka 
    Premawardhena, A.P. (Faculty of Medicine, University of Kelaniya, Sri Lanka, 2016)
    Haemoglobin E β-thalassaemia is the commonest cause of non-transfusion dependent thalassaemia in Sri Lanka. It is a disease exclusively restricted to people of South and Southeast Asian descent. It is phenotypically very ...
  • Survival and complications in patients with haemoglobin E thalassaemia in Sri Lanka: a prospective, longitudinal cohort study. 
    Premawardhena, A.P.; Ediriweera, D.S.; Sabouhanian, A.; Allen, A.; Rees, D.; de Silva, S.; Perera, W.; Katugaha, N.; Arambepola, M.; Yamashita, R.C.; Mettananda, S.; Jiffry, N.; Mehta, V.; Cader, R.; Bandara, D.; St Pierre, T.; Muraca, G.; Fisher, C.; Kirubarajan, A.; Khan, S.; Allen, S.; Lamabadusuriya, S.P.; Weatherall, D.J.; Olivieri, N.F. (Elsevier Ltd, 2022)
    Background: Worldwide, haemoglobin E β-thalassaemia is the most common genotype of severe β-thalassaemia. The paucity of long-term data for this form of thalassaemia makes evidence-based management challenging. We did a ...

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