Browsing by Author "Wijerathne, B.T.B."

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Chronic kidney disease of unknown aetiology: the tip of the iceberg?
(Ceylon Journal of Medical Science, 2018) Wijerathne, B.T.B.; Meier, R.J.; Salgado, L.S.S.; Rathnayake, G.K.; Kumara, S.S.; Agampodi, S.B.
No abstract available.
Dermatoglyphics in kidney diseases: a review
(SpringerOpen, 2016) Wijerathne, B.T.B.; Meier, R.J.; Salgado, S.S.; Agampodi, S.B.
Kidney diseases are becoming a major cause of global burden with high mortality and morbidity. The origins of most kidney diseases are known, but for some the exact aetiology is not yet understood. Dermatoglyphics is the scientific study of epidermal ridge patterns and it has been used as a non-invasive diagnostic tool to detect or predict different medical conditions that have foetal origin. However, there have been a limited number of studies that have evaluated a dermatoglyphic relationship in different kidney diseases. The aim of this review was to systematically identify, review and appraise available literature that evaluated an association of different dermatoglyphic variables with kidney diseases. This review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. The PubMed® (Medline), POPLINE, Cochrane Library and Trip Database and grey literature sources such as OpenGrey, Google Scholar, and Google were searched to earliest date to 17 April 2014. Of the 36 relevant publications, 15 were included in the review. Of these studies, there are five case reports, seven case series and three comparative studies. Possible association of dermatoglyphics with Wilms tumor (WT) had been evaluated in two comparative studies and one case series that found fewer whorls and a lower mean total ridge count (TRC). Another study evaluated adult polycystic kidney disease (APCD) type III that revealed lower TRC means in all cases. All other case series and case reports describe dermatoglyphics in various kidney disease such as acro-renal-ocular syndrome, potter syndrome, kabuki makeup syndrome, neurofaciodigitorenal syndrome, syndactyly type V, ring chromosome 13 syndrome, trisomy 13 syndrome and sirenomelia. It is evident that whorl pattern frequency and TRC have been used widely to investigate the uncertainty related to the origin of several kidney diseases such as WT and APCD type III. However, small sample sizes, possibly methodological issues, and discrepancy in the make up between cases and control groups limits interpretation of any significant findings. Future studies with proper protocol, adequate cases, and control groups may provide stronger evidence to resolve uncertainty related to the aetiology of kidney diseases.
Qualitative and quantitative Dermatoglyphics of Chronic Kidney Disease of Unknown Origin (CKDu) in Sri Lanka
(Japan Society of Physiological Anthropology, 2020) Wijerathne, B.T.B.; Meier, R.J.; Salgado, S.S.; Agampodi, S.B.
BACKGROUND: Dermatoglyphics has been used widely in fields of medicine as a non-invasive diagnostic tool and an early assessment of risk for certain medical conditions. It reflects disturbances in fetal development during early prenatal weeks 14-22 when fingerprints develop. Dermatoglyphic asymmetry has been used to measure developmental instability during a specific period of human fetal development. Thus, the present study was planned to investigate whether digital and palmar dermatoglyphics of chronic kidney disease of unknown origin (CKDu) patients in Sri Lanka are different from healthy people. METHODS: A case control study was carried out among CKDu patients (90 males, 90 females) from a CKDu endemic area and gender-matched two control groups; one group from a CKDu endemic region (90 males, 90 females) and another group from a CKDu non-endemic region (90 males, 90 females). Dermatoglyphics were obtained using photographic methods. Both qualitative and quantitative dermatoglyphic variables were defined and analyzed according to standard criteria. Both directional (DA) and fluctuating asymmetry (FA) were assessed. RESULTS: Several qualitative dermatoglyphic variables had significant association with CKDu. The triradii a1 variable was less evident in palms of CKDu cases in both genders when compared to both control groups. The FA of pattern discordance (right vs left hands) between CKDu cases and control group were significant in several digits. The FA of the ridge count was found significant in several digits, and also significant for A-B ridge count and total ridge count. CONCLUSIONS: Based on these results, it is proposed that the mechanisms responsible for the development of CKDu might be associated with those responsible for FA observed in CKDu patients. Accordingly, a diagnostic tool based on FA could be developed for predicting risk prior to the development of CKDu. KEYWORDS: Chronic kidney disease; Dermatoglyphics; Fluctuating asymmetry; Prenatal stress; Sri Lanka.
Uncommon palm prints: Can they be used for forensic identification?
(Wiley, 2016) Wijerathne, B.T.B.; Meier, R.J.; Salgado, S.S.; Agampodi, S.B.
The uses of dermatoglyphics in kidney diseases: a systematic review
(Faculty of Medicine, University of Kelaniya, Sri Lanka, 2016) Wijerathne, B.T.B.; Meier, R.J.; Salgado, S.S.; Agampodi, S.B.
BACKGROUND: Kidney disease causes significant global burden with high mortality and morbidity. Dermatoglyphic has been used as a non- invasive diagnostic tool to detect or predict different medical conditions that has foetal origin. However, a scarce number of studies have evaluated a dermatoglyphic relationship in different kidney diseases. OBJECTIVE: The aim of this review was to systematically identify, review and appraise literature and evaluate the association of different dermatoglyphic variables with different types of kidney diseases. METHODS: This review is reported according to PRISMA checklist. The PubMed, POPLINE, Cochrane Library, Trip Database, OpenGrey and Google Scholar databases were searched to earliest date to 17 April 2014. Of the 36 relevant publications, 15 (5 case reports, 7 cases series and 3 comparative studies) were included in the review. RESULTS: Possible association of dermatoglyphic with Wilms tumor (WT) had been evaluated in 2 comparative studies and one case series and found low occurrence of whorls and total ridge count (TRC). Another study evaluated adult polycystic kidney disease (APCD) which revealed lower TRC in cases. All other studies described dermatoglyphics in various kidney diseases without any significant associations. CONCLUSIONS: It is evident that whorl pattern and TRC have been used to investigate the uncertainty related to origin of several kidney diseases, such as, WT and APCD type III. However, limited sample size and/or inconsistency between cases and control groups confines interpretation of any significant findings. Future dermatoglyphics studies with proper protocols and adequate sample sizes may provide stronger evidence to resolve uncertainty related to the etiology of kidney diseases.