Browsing by Author "Peiris, J.B."
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Item A Delayed onset cerebellar syndrome complicating falciparum malaria(Sri Lanka Medical Association, 1986) de Silva, H.J.; Gamage, R.; Herath, H.K.; Abeysekera, D.T.; Peiris, J.B.No abstract availableItem Immune activation during cerebellar dysfunction following Plasmodium falciparum malaria(Oxford University Press, 1992) de Silva, H.J.; Hoang, P.; Dalton, H.; de Silva, N.R.; Jewell, D.P.; Peiris, J.B.Evidence for immune activation was investigated in 12 patients with a rare syndrome of self-limiting, delayed onset cerebellar dysfunction following an attack of falciparum malaria which occurred 18-26 d previously. Concentrations of tumour necrosis factor, interleukin 6 and interleukin 2 were all significantly higher in serum samples of patients during cerebellar ataxia than in recovery sera and in the sera of 8 patients who did not develop delayed cerebellar dysfunction following an attack of falciparum malaria. Cytokine concentrations in the cerebrospinal fluid were also significantly higher in ataxic patients than in controls. These findings suggest that immunological mechanisms may play a role in delayed cerebellar dysfunction following falciparum malaria.Item A Self-limiting midline cerebellar syndrome. Is falciparum malaria the cause?(Sage Publishing, 1988) de Silva, H.J.; Gamage, R.; Herath, H.K.; Peiris, J.B.; Abeysekera, D.T.No Abstract AvailableItem Spinal decompression sickness--a report of two cases(Sri Lanka Medical Association, 1986) de Silva, H.J.; Nanayakkara, S.N.; Aloysius, D.; Peiris, J.B.No Abstract AvailableItem The Treatment of Guillain-Barre syndrome by modified plasma exchange--a cost effective method for developing countries(BMJ Publishing Group, 1987) de Silva, H.J.; Gamage, R.; Herath, H.K.; Karunanayake, M.G.; Peiris, J.B.Six patients with the Guillain-Barré syndrome were treated by modified plasma exchange. Five of them showed a rapid improvement which was not consistent with the natural history of the disease. The improvement was assessed by monitoring vital capacity and muscle power, grading the ability to perform motor functions and by the duration of the hospital stay. The method of plasma exchange we used was simpler and cheaper than the conventional method. We recommend the use of our method, especially in developing countries with financial constraints and poor facilities.