Browsing by Author "Padumadasa, S."
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Item Abnormal labour(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract availableItem Acute and subacute toxicity studies of the Ethyl Acetate soluble proanthocyanidins of the immature inflorescence of Cocos nucifera L. in female Wistar Rats.(Hindawi Pub. Co., 2019) Ekanayake, C.P.; Thammitiyagodage, M.G.; Padumadasa, S.; Seneviratne, B.; Padumadasa, C.; Abeysekera, A.M.Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.Item Acute fatty liver of pregnancy(Taylor and Francis Group, 2021) de Silva, J.; Padumadasa, S.No abstract availableItem Acute pancreatitis in pregnancy – Nip in the bud (Case Reports)(Sri Lanka college of Obstetricians & Gynaecologists, 2021) Padumadasa, S.; Siriwardana, R.C.No abstract availableItem Acute uterine inversion(Taylor and Francis Group, 2021) Padumadasa, S.; Gunawardana, K.No abstract availableItem Item Item Assisted vaginal breech delivery(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract availableItem Cardiac emergencies in obstetrics(Taylor and Francis Group, 2021) Padumadasa, S.; Rajapakse, S.No abstract availableItem A Case of pleural endometriosis(Galle Medical Association., 2002) Samarage, H.; Padumadasa, S.; Gamage, N.No abstract availableItem Difficult caesarean delivery(Taylor and Francis Group, 2021) Padumadasa, S.; Senanayake, H.No abstract availableItem Eclampsia and pre-eclampsia with severe features(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract availableItem Emergency obstetric hysterectomy(Taylor and Francis Group, 2021) Padumadasa, S.; Wijesinghe, P.No abstract availableItem External cephalic version(Taylor and Francis Group, 2021) Goonewardene, M.; Padumadasa, S.No abstract availableItem A Fatal case of dissecting aortic root aneurysm due to undiagnosed Marfan syndrome in the puerperium(Sri Lanka College of Obstetricians and Gynaecologists, 2012) Nishad, A.A.N.; Herath, R.; Silva, G.R.C.; Mohamed, R.; Wijesinghe, P.; Padumadasa, S.; Premawardhena, A.; Premaratna, R.Aortic dissection in pregnancy is a lethal cardiovascular complication in women with Marfan syndrome. The course of the treatment would be decided upon by the size of aortic root dilation. We report a case where the unawareness of the diagnosis of Marfan syndrome antenatally led to disastrous post partum consequences even after an uneventful childbirth.Item Induction of labor in women over 35 years: How does it affect the outcome?(Sri Lanka College of Obstetricians & Gynaecologists, 2016) Tiran, D.; Janitha, G.; Chaya, H.; Padumadasa, S.; Wijesinghe, P.OBJECTIVE: Compare fetal and labor outcomes following induction of labor in singleton pregnant women over 35 years (>35) with women between 20 to 30 years (20-30) METHOD: This was a retrospective study carried out at North Colombo Teaching Hospital using North Colombo Obstetric Database (NORCOD) between March 2014 and May 2016. Two hundred and ninety six singleton pregnancies that underwent induction of labor were included. Women had been categorized into two groups based on their age. They were 20-30 years (2030) and above 35 years (>35). Two groups were matched against their booking visit body mass index. Labor and fetal outcomes of each group were assessed. RESULT: Lower segment Caesarean section (LSCS) rates observed in 20-30 and >35 groups were 16.2% (N=24) and 17.6% (N=26) respectively (P>0.05). Newborns of induced pregnancies of 20-30 mothers had an APGAR <7 at 5min in 1.4% (N=2) and 2.7% (N=4) babies of women >35 had an APGAR <7 at 5 min (P>0.05). Induced pregnancies of 20-30 mothers reported 16.2% (N=24) NICU admissions and >35 years group had 20.3% (N=30) NICU admissions (P>0.05). CONCLUSION: There is no significant difference between the two groups in terms of LSCS rates, low 5 min APGAR and NICU admissions.Item Induction of labor in women over 35 years: How does it affect the outcome?(Sri Lanka College of Obstetricians & Gynaecologists, 2016) Dias, T.D.; Janitha, G.; Chaya, H.; Padumadasa, S.; Wijesinghe, P.OBJECTIVE: Compare fetal and labor outcomes following induction of labor in singleton pregnant women over 35 years (>35) with women between 20 to 30 years (20-30) METHOD: This was a retrospective study carried out at North Colombo Teaching Hospital using North Colombo Obstetric Database (NORCOD) between March 2014 and May 2016. Two hundred and ninety six singleton pregnancies that underwent induction of labor were included. Women had been categorized into two groups based on their age. They were 20-30 years (20- 30) and above 35 years (>35). Two groups were matched against their booking visit body mass index. Labor and fetal outcomes of each group were assessed. RESULTS: Lower segment Caesarean section (LSCS) rates observed in 20-30 and >35 groups were 16.2% (N=24) and 17.6% (N=26) respectively (P>0.05). Newborns of induced pregnancies of 20-30 mothers had an APGAR <7 at 5min in 1.4% (N=2) and 2.7% (N=4) babies of women >35 had an APGAR <7 at 5 min (P>0.05). Induced pregnancies of 20-30 mothers reported 16.2% (N=24) NICU admissions and >35 years group had 20.3% (N=30) NICU admissions (P>0.05). CONCLUSION: There is no significant difference between the two groups in terms of LSCS rates, low 5 min APGAR and NICU admissions.Item Instrumental vaginal delivery(Taylor and Francis Group, 2021) Goonewardene, M.; Padumadasa, S.No abstract availableItem Internal iliac artery ligation – time to revive a dying art(Sri Lanka College of Obstetricians & Gynaecologists, 2020) Padumadasa, S.No Abstract availableItem Internal podalic version and breech extraction(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract available